Parkin antibody (AA 1-144)

Catalog No. ABIN7193428

Product Details anti-Parkin Antibody

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Binding Specificity: AA 1-144

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Parkin antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: PRKN Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PRKN (AA: 1-144) expressed in E. Coli.

Clone: 6F5D2

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Alternative Name: PRKN (PARK2 Products)

Background:

Description:

The precise function of this gene is unknown, however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Aliases: PDJ, AR-JP, LPRS2, PARK2

Molecular Weight: 51.6kDa

Gene ID: 5071

UniProt: O60260

Pathways: Autophagy, Ubiquitin Proteasome Pathway