NR4A2 antibody (AA 301-400)

Catalog No. ABIN725915

Product Details anti-NR4A2 Antibody

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Binding Specificity: AA 301-400

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR4A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: 90 % sequence similarity with Nuclear receptor subfamily 4 group A member 3

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nurr1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Alternative Name: Nurr1 (NR4A2 Products)

Background:

Synonyms: Nur-ralated factor 1, Nuclear receptor-related factor 1, Orphan nuclear receptor NR4A2, Orphan nuclear receptor NURR1, Regenerating liver nuclear receptor 1, RNR-1, SL-322, Nuclear orphan receptor HZF-3, T-cell nuclear receptor NOT,HZF 3, HZF3, Immediate-early response protein NOT, Intermediate early receptor protein, NGFI B/nur77 beta type transcription factor homolog, NOT, NR4A2, NR4A2_HUMAN, Nuclear receptor subfamily 4 group A member 2, Nur related protein 1 homolog, Nurr 1,RNR 1, RNR1, TINUR, Transcriptionally inducible nuclear receptor, Transcriptionally inducible nuclear receptor related, Transcriptionally inducible nuclear receptor related 1, Transcriptionally-inducible nuclear receptor.

Background: Nuclear receptor and transcription factor, plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

Gene ID: 4929

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway