Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Synonyms: CKBBP2, CKII beta associating protein, CKII beta binding protein 2, CKII beta-associating protein, CR6 interacting factor 1, CR6-interacting factor 1, CR1, G45IP_HUMAN, Gadd45gip1, growth arrest and DNA damage inducible, gamma interacting protein 1, Growth arrest and DNA damage-inducible proteins-interacting protein 1, p53 responsive gene 6, p53 responsive gene 6 protein, p53-responsive gene 6 protein, Papillomavirus L2 interacting nuclear protein 1, Papillomavirus L2-interacting nuclear protein 1, PLINP 1, PLINP-1, PLINP1, PRG6.