ZMIZ2 antibody (Center)

Catalog No. ABIN783450

Product Details anti-ZMIZ2 Antibody

Target: ZMIZ2 (Zinc Finger, MIZ-Type Containing 2 (ZMIZ2))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZMIZ2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects ZMIZ2 at Center. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human ZIMP7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZMIZ2

Target: ZMIZ2 (Zinc Finger, MIZ-Type Containing 2 (ZMIZ2))

Alternative Name: ZMIZ2 (ZMIZ2 Products)

Background: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR)- mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification. At least four isoforms are known to exist.Synonyms: HRIHFB2007, KIAA1886, ZIMP7, Zinc finger MIZ domain-containing protein 2

Gene ID: 83637

NCBI Accession: NP_113637

UniProt: Q8NF64