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DPYSL2 antibody (Dihydropyrimidinase-Like 2) (C-Term) Primary Antibody

DPYSL2 Reactivity: Human, Mouse, Rat EIA, IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN784201
$495.00
Plus shipping costs $45.00
50 μg
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Delivery in 6 to 8 Business Days
  • Target
    DPYSL2
    Binding Specificity
    C-Term
    • 35
    • 17
    • 10
    • 9
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat
    • 96
    • 68
    • 64
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This DPYSL2 antibody is un-conjugated
    • 44
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Application
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 57
    • 35
    • 27
    • 24
    • 16
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Specificity
    This antibody detects endogenous levels of total DPYSL2 protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide - KLH conjugated Remarks: Antigen Modification: C-Terminus
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DPYSL2
    Alternative Name
    DPYSL2 / CRMP2 (DPYSL2 Antibody Abstract)
    Synonyms
    CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, TOAD-64, crmp2, dhprp2, drp-2, drp2, unc-33, unc33, dpysl2, CRMP 2, PCRMP 2, PCRMP-2, PCRMP2, PfCRMP 2, PfCRMP-2, AI851130, Crmp2, Musunc33, Ulip2, CRMP2A, dihydropyrimidinase like 2, dihydropyrimidinase-like 2, dihydropyrimidinase like 2 L homeolog, dihydropyrimidinase-like 2b, cysteine repeat modular protein 2, putative, DPYSL2, dpysl2.L, dpysl2b, PfCRMP2, dpysl2, Dpysl2
    Background
    DRP-2, also known as Collapsin Response Mediator Protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients.Synonyms: Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3
    Gene ID
    1808
    NCBI Accession
    NP_001184222
    Pathways
    Regulation of Cell Size
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