DPYSL2 antibody (C-Term)

Catalog No. ABIN784201

Product Details anti-DPYSL2 Antibody

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYSL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects endogenous levels of total DPYSL2 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated Remarks: Antigen Modification: C-Terminus

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DPYSL2

Target: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Alternative Name: DPYSL2 / CRMP2 (DPYSL2 Products)

Synonyms: CRMP-2 antibody, CRMP2 antibody, DHPRP2 antibody, DRP-2 antibody, DRP2 antibody, N2A3 antibody, ULIP-2 antibody, ULIP2 antibody, TOAD-64 antibody, crmp2 antibody, dhprp2 antibody, drp-2 antibody, drp2 antibody, unc-33 antibody, unc33 antibody, dpysl2 antibody, CRMP 2 antibody, PCRMP 2 antibody, PCRMP-2 antibody, PCRMP2 antibody, PfCRMP 2 antibody, PfCRMP-2 antibody, AI851130 antibody, Crmp2 antibody, Musunc33 antibody, Ulip2 antibody, CRMP2A antibody, dihydropyrimidinase like 2 antibody, dihydropyrimidinase-like 2 antibody, dihydropyrimidinase like 2 L homeolog antibody, dihydropyrimidinase-like 2b antibody, cysteine repeat modular protein 2, putative antibody, DPYSL2 antibody, dpysl2.L antibody, dpysl2b antibody, PfCRMP2 antibody, dpysl2 antibody, Dpysl2 antibody

Background: DRP-2, also known as Collapsin Response Mediator Protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients.Synonyms: Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3

Gene ID: 1808

NCBI Accession: NP_001184222

Pathways: Regulation of Cell Size