PPARGC1A antibody (AA 151-250)

Catalog No. ABIN873223

Product Details anti-PPARGC1A Antibody

Target: PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A))

Binding Specificity: AA 151-250

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARGC1A antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Predicted Reactivity: Mouse,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PGC1 alpha

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PPARGC1A

Target: PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A))

Alternative Name: PGC1 alpha (PPARGC1A Products)

Synonyms: PPARGC1A, PPARGC1, A830037N07Rik, ENSMUSG00000079510, Gm11133, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, PGC1, PGC1A, LEM6, PGC-1(alpha), AVPGC-1ALPHA, PPARG coactivator 1 alpha, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, PPARG coactivator 1 alpha S homeolog, PPARGC1A, Ppargc1a, ppargc1a.S

Background:

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq].

Subcellular location: Nucleus

Synonyms: LEM6, Ligand effect modulator 6, PERC, Peroxisome prolerative activated receptor, gamma, coactivator 1 alpha, Peroxisome prolerative activated receptor, gamma, coactivator 1, Peroxisome prolerator activated receptor gamma coactivator 1 alpha, peroxisome prolerator-activated receptor gamma coactivator 1 beta, Peroxisome prolerator-activated receptor gamma coactivator 1-alpha, Peroxisome prolerator-activated receptor gamma coactivator 1-beta, peroxisome prolerator-activated receptor gamma, coactivator 1 beta, PGC 1 alpha, PGC 1 alpha, PGC 1v, PGC-1beta, PGC-1-alpha, PGC-1-beta, PGC-1-related estrogen receptor alpha coactivator, PGC1, PGC1alpha, PGC1A, PGC1v, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1, PPAR gamma coactivator variant form, PPAR gamma coactivator-1beta, PPAR-gamma coactivator 1-alpha, PPAR-gamma coactivator 1-beta, PPARGC 1 alpha, PPARGC-1-alpha, PPARGC-1-beta, PPARGC1, PPARGC1A, Ppargc1b, PRGC1_HUMAN, PRGC2_HUMAN.

Molecular Weight: 91-110kDa

Gene ID: 10891

UniProt: Q9UBK2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Brown Fat Cell Differentiation