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IRF3 antibody (Interferon Regulatory Factor 3) (AA 51-150) (Alexa Fluor 488) Primary Antibody

IRF3 Reactivity: Human, Mouse, Rat, Cow, Monkey IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN903063
$442.20
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    IRF3
    Binding Specificity
    • 16
    • 16
    • 14
    • 14
    • 13
    • 9
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivity
    • 145
    • 86
    • 53
    • 30
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Monkey
    Host
    • 150
    • 15
    • 2
    Rabbit
    Clonality
    • 137
    • 30
    Polyclonal
    Conjugate
    • 94
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IRF3 antibody is conjugated to Alexa Fluor 488
    Application
    • 115
    • 70
    • 39
    • 28
    • 26
    • 24
    • 21
    • 12
    • 11
    • 11
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Cow, Dog, Horse, Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IRF3
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 4 °C
    Expiry Date
    12 months
  • Target
    IRF3
    Alternative Name
    IRF3 (IRF3 Antibody Abstract)
    Synonyms
    irf3, IRF3, C920001K05Rik, IRF-3, interferon regulatory factor 3, interferon regulatory factor 7, irf3, IRF3, irf-3, Irf3, IRF7
    Background

    Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

    Gene ID
    3661
    UniProt
    Q14653
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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