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MME antibody (FITC)

Name: MME antibody (FITC)
Brand: antibodies-online
SKU: ABIN93932
Price: 503.21 USD
Availability: InStock

MME Reactivity: Human FACS Host: Mouse Monoclonal MEM-78 FITC

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD10 (MEM-78) FITC antibody (20 μL reagent / 100 μL of peripheral whole blood). (MME antibody (FITC))

FACS

Surface staining of NALM-6 human pre-B cell leukemia cell line with anti-human CD10 (MEM-78) PE. (MME antibody (FITC))

FACS

Surface staining of human peripheral blood with anti-human CD10 (MEM-78) FITC. (MME antibody (FITC))

FACS

Separation of human neutrophil granulocytes (red-filled) from 10 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD10 (MEM-78) FITC antibody (20 μL reagent / 100 μL of peripheral whole blood). (MME antibody (FITC))

FACS

4 images

(1 reference)

Catalog No. ABIN93932

Datasheet as PDF

Target See all MME Antibodies

MME (Membrane Metallo-Endopeptidase (MME))
Reactivity
181

45

38

3

2

2

2

2

2

1

1

1

1
Human
Host
96

90

2
Mouse
Compatible Secondaries
Clonality
104

83

2
Monoclonal
Conjugate
108

17

14

10

7

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MME antibody is conjugated to FITC
Application
102

74

73

59

35

26

19

18

10

8

5

5

3

2

2

1

1

1

1

1
Flow Cytometry (FACS)

Purpose

Anti-Hu CD10 FITC

Specificity

The antibody MEM-78 reacts with an extracellular epitope CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Cross-Reactivity (Details)

Human

Purification

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen

NALM-6 human pre-B cell line

Clone

MEM-78

Isotype

IgG1

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MME Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated

Application Notes

Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Restrictions

For Research Use only
Reconstitution

No reconstitution is necessary.

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Do not freeze.
Avoid prolonged exposure to light.

Storage

4 °C

Storage Comment

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Angelisová, Drbal, Horejsí, Cerný: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, (1999) (PubMed).
Target

MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name

CD10 (MME Products)

Background

Membrane metalloendopeptidase,CD10 (neutral endopeptidase –, NEP, common acute lymphocytic leukemia antigen –, CALLA, membrane metallo-endopeptidase –, MME, enkefalinase) is a 100- kDa cell surface zinc metalloprotease, cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.,CALLA, Neprilysin, Neutral endopeptidase, Enkephalinase, Atriopeptidase, MME

Gene ID

4311

UniProt

P08473

Pathways

RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration