CD59 antibody
(2 references)-
- Target See all CD59 Antibodies
- CD59
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Reactivity
- Human, Pig
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD59 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Functional Studies (Func)
- Specificity
- The antibody MEM-129 reacts with CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissus.
- Cross-Reactivity (Details)
- Human, Porcine
- Purification
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Human peripheral blood lymphocytes
- Clone
- MEM-129
- Isotype
- IgM
- Top Product
- Discover our top product CD59 Primary Antibody
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anti-CD59 (CD59) (AA 31-111) antibody
CD59 Reactivity: Human FACS, IHC, ELISA, ICC Host: Mouse Monoclonal 8D2B8 unconjugated
anti-CD59 (CD59) (AA 74-110) antibodyCD59 Reactivity: Human WB, FACS, IF, IHC (p) Host: Rabbit Polyclonal RB56691 unconjugated
anti-CD59 (CD59) antibodyCD59 Reactivity: Human FACS, IP, IHC (p) Host: Mouse Monoclonal MEM-43 unconjugated
anti-CD59 (CD59) antibodyCD59 Reactivity: Human, Mouse WB, FACS, IP, IHC (p) Host: Mouse Monoclonal MEM-43-5 unconjugated
anti-CD59 (CD59) (AA 31-111) antibodyCD59 Reactivity: Human WB, FACS, IHC, ELISA, IF/ICC Host: Mouse Monoclonal unconjugated
anti-CD59 (CD59) (AA 23-105) antibodyCD59 Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-CD59 (CD59) (AA 1-128) antibodyCD59 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3G6 unconjugated
anti-CD59 (CD59) (AA 26-102) antibodyCD59 Reactivity: Human WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-CD59 (CD59) (AA 52-100) antibodyCD59 Reactivity: Human FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
anti-CD59 (CD59) antibodyCD59 Reactivity: Human WB, IHC, ELISA Host: Mouse Monoclonal 2E11B6 unconjugated
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- Application Notes
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Functional application: The antibody MEM-129 activates T cells.
Flow cytometry: Recommended dilution: 1-4 μg/mL. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- HEPES buffered saline (HBS), pH 7.0
- Preservative
- Azide free
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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-
: "Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, (1997) (PubMed).
: "CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells." in: Blood, Vol. 85, Issue 9, pp. 2402-13, (1995) (PubMed).
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: "Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, (1997) (PubMed).
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- Target
- CD59
- Alternative Name
- CD59 (CD59 Products)
- Background
- CD59 Molecule,CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.,MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN
- Gene ID
- 966
- UniProt
- P13987
- Pathways
- Complement System
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