HLA-DP/DR antibody

Catalog No. ABIN94346

Product Details anti-HLA-DP/DR Antibody

Target: HLA-DP/DR (MHC Class II HLA-DP/DR (HLA-DP/DR))

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-DP/DR antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Anti-HLA-DR/DP Purified

Specificity: The antibody HL-38 recognizes an extracellular common epitope on beta-chain of human HLA-DR and HLA-DP. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).

Cross-Reactivity (Details): Human, Porcine

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Raji Burkitt's lymphoma cell line

Clone: HL-38

Isotype: IgG2a

Application Details

Application Notes: Western blotting: Recommended dilution: 1 μg/mL
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-HLA-DP/DR antibody (ABIN94346)

Horejsí, N?mec, Angelisová, Kristofová, Gorga, Hilgert: "Characterization of seven new monoclonal antibodies against human DR, DR + DP and DQ1 + DQ3 antigens." in: Tissue antigens, Vol. 28, Issue 5, pp. 288-97, (1987) (PubMed).

Target Details for HLA-DP/DR

Target: HLA-DP/DR (MHC Class II HLA-DP/DR (HLA-DP/DR))

Alternative Name: HLA-DR/DP (HLA-DP/DR Products)

Background: HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.