L1CAM antibody (C-Term)

Catalog No. ABIN951209

Product Details anti-L1CAM Antibody

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Binding Specificity: AA 1153-1182, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects CD171 / L1CAM at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a protein A column, followed by peptide affinity purification.

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 1153-1182aa) of human CD171 / L1CAM.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: CD171 / L1CAM (L1CAM Products)

Background: L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.Synonyms: CAML1, MIC5, N-CAM L1, Neural cell adhesion molecule L1

Gene ID: 3897

NCBI Accession: NP_000416

Pathways: Synaptic Membrane