BMPR1B antibody (Bone Morphogenetic Protein Receptor, Type IB) (AA 141-168)

Details for Product anti-BMPR1B Antibody No. ABIN951454
Antigen
  • ALK6
  • BMPR-IB
  • FecB
  • alk-6
  • alk6
  • cdw293
  • alk6b
  • zgc:172219
  • BMPR1B
  • AI385617
  • ALK-6
  • AV355320
  • Acvrlk6
  • Alk6
  • BMPR-1B
  • CFK-43a
  • SKR6
  • BR1b
  • alk6tr
  • bmpr1b
  • zALK-6
  • zgc:92220
  • CDw293
  • BMP15
  • BMPRIB
  • RPK-1
  • bone morphogenetic protein receptor type 1B
  • bone morphogenetic protein receptor, type IBb
  • bone morphogenetic protein receptor, type 1B
  • bone morphogenetic protein receptor, type IBa
  • BMPR1B
  • bmpr1b
  • bmpr1bb
  • Bmpr1b
  • bmpr1ba
Epitope
AA 141-168, Middle Region
16
16
16
14
11
10
9
9
7
7
7
7
7
7
7
4
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
173
63
24
1
1
1
1
1
1
Host
Rabbit
154
19
Clonality
Polyclonal
Conjugate
This BMPR1B antibody is un-conjugated
13
12
12
12
12
10
2
2
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
138
102
58
15
13
5
5
4
4
3
2
2
2
1
Options
Immunogen KLH conjugated synthetic peptide between 141-168 amino acids from the Central region of human BMPR1B
Isotype Ig Fraction
Specificity This antibody reacts to CDw293.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Plasmids, Primers & others Plasmids, Primers & others BMPR1B products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CDw293 / BMPR1B (BMPR1B Antibody Abstract)
Background This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.Synonyms: ALK6, Bone morphogenetic protein receptor type-1B
Gene ID 658
NCBI Accession NP_001194
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Image no. 1 for anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 141-168), (Middle Region) antibody (ABIN951454) BMPR1B Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin...
Image no. 2 for anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 141-168), (Middle Region) antibody (ABIN951454) BMPR1B Antibody (Center) western blot analysis in U251 cell line lysates (35µg/lane)....
Background publications Mick, Todorov, Smalley, Hu, Loo, Todd, Biederman, Byrne, Dechairo, Guiney, McCracken, McGough, Nelson, Reiersen, Wilens, Wozniak, Neale, Faraone: "Family-based genome-wide association scan of attention-deficit/hyperactivity disorder." in: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 49, Issue 9, pp. 898-905.e3, 2010 (PubMed).

Joslyn, Ravindranathan, Brush, Schuckit, White: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

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