BMPR1B antibody (Bone Morphogenetic Protein Receptor, Type IB) (AA 141-168)

Details for Product anti-BMPR1B Antibody No. ABIN951454
Target
Binding Specificity
AA 141-168, Middle Region
16
15
15
14
10
9
9
9
7
7
7
7
7
7
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
137
47
21
1
1
1
1
1
1
Host
Rabbit
122
15
Clonality
Polyclonal
Conjugate
This BMPR1B antibody is un-conjugated
13
12
12
12
12
10
2
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
113
92
44
13
10
5
3
2
2
2
2
2
2
1
Options
Immunogen KLH conjugated synthetic peptide between 141-168 amino acids from the Central region of human BMPR1B
Isotype Ig Fraction
Specificity This antibody reacts to CDw293.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Target
Alternative Name CDw293 / BMPR1B (BMPR1B Antibody Abstract)
Background This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.Synonyms: ALK6, Bone morphogenetic protein receptor type-1B
Gene ID 658
NCBI Accession NP_001194
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Images
Image no. 1 for anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 141-168), (Middle Region) antibody (ABIN951454) BMPR1B Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin...
Image no. 2 for anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (AA 141-168), (Middle Region) antibody (ABIN951454) BMPR1B Antibody (Center) western blot analysis in U251 cell line lysates (35µg/lane)....