Hairy and Enhancer of Split 6 (Drosophila) (HES6) (AA 13-42), (N-Term) antibody

Details for Product No. ABIN952723
Antigen
  • YF-30
  • her13.2
  • AI326893
  • bHLHb41
  • HES-6
  • bHLHc23
  • hes family bHLH transcription factor 6
  • hairy and enhancer of split 6
  • hes6
  • Hes6
  • HES6
Epitope
N-Term, AA 13-42
16
9
7
7
4
2
1
1
1
1
Reactivity
Human
72
7
7
4
2
2
1
1
1
1
1
Host
Rabbit
60
12
Clonality
Polyclonal
Conjugate
Un-conjugated
4
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
57
29
14
7
4
1
1
1
1
1
Options
Immunogen KLH conjugated synthetic peptide between 13~42 amino acids from the N-terminal region of human HES6
Isotype Ig Fraction
Specificity This antibody recognizes Human HES (N-term).
Purification Protein A column, followed by peptide affinity purification
Antigen
Alternative Name HES6 (HES6 Antibody Abstract)
Background HES6 is a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. The protein functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus.Synonyms: BHLHB41, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, Transcription cofactor HES-6
Molecular Weight 24129 Da
Gene ID 55502
NCBI Accession NP_001136325
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Image no. 1 for anti-Hairy and Enhancer of Split 6 (Drosophila) (HES6) (AA 13-42), (N-Term) antibody (ABIN952723) Western blot analysis of HES6 Antibody (N-term) in MCF-7 cell line lysates (35ug/lane...
Background publications Glubb, Joyce, Kennedy: "Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response." in: Neuroscience letters, Vol. 460, Issue 2, pp. 185-90, 2009 (PubMed).

de Krom, Staal, Ophoff, Hendriks, Buitelaar, Franke, de Jonge, Bolton, Collier, Curran, van Engeland, van Ree: "A common variant in DRD3 receptor is associated with autism spectrum disorder." in: Biological psychiatry, Vol. 65, Issue 7, pp. 625-30, 2009 (PubMed).

Eun, Lee, Hong, Kim, Lee, Kim, Sun, Kim: "Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5939-49, 2008 (PubMed).

Scheffer, Sage, Corey, Pingault: "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells." in: FEBS letters, Vol. 581, Issue 24, pp. 4651-6, 2007 (PubMed).

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