TAB2 antibody (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2)

Details for Product anti-TAB2 Antibody No. ABIN967128
Antigen
  • CHTD2
  • MAP3K7IP2
  • 1110030N06Rik
  • A530078N03Rik
  • Map3k7ip2
  • mKIAA0733
  • map3k7ip2
  • zgc:77446
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2
  • TAB2
  • Tab2
  • tab2
Reactivity
Human
48
16
12
6
4
3
3
3
3
1
1
1
1
Host
Mouse
33
13
3
Clonality (Clone)
Monoclonal ()
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
32
23
15
10
9
6
4
3
2
Options
Immunogen Purified recombinant fragment of human TAB2 expressed in E. Coli.
Clone 3B5
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others TAB2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TAB2 (TAB2 Antibody Abstract)
Background The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Synonyms: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2
Molecular Weight 80kDa
Gene ID 23118
Pathways TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
Application Notes Western Bloting: 1/500 - 1/2000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, 2010 (PubMed).

Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, 2006 (PubMed).

Cashin, Sci: "Two terms--one meaning: the conundrum of contemporary nomenclature in autism." in: Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc, Vol. 19, Issue 3, pp. 137-44, 2006 (PubMed).

Background publications Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." in: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, 2006 (PubMed).

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