VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (AA 20-764)

Details for Product anti-KDR Antibody No. ABIN969231
Antigen
Epitope
AA 20-764
66
61
49
49
29
23
19
18
16
16
15
14
12
10
9
9
8
7
7
7
7
7
7
6
6
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
598
356
212
26
7
5
5
4
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Host
Mouse
562
115
21
2
2
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VEGFR2 antibody is un-conjugated
44
26
25
22
14
12
10
10
10
10
10
10
3
3
3
3
3
3
3
2
2
2
2
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
457
264
245
141
118
103
30
29
26
22
22
19
16
8
8
4
2
1
Options
Immunogen Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Clone 4B4
Isotype IgG1
Purification Ascites
Antigen
Alternative Name KDR (KDR Antibody Abstract)
Background KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Molecular Weight 152 kDa
Gene ID 3791
HGNC 3791
Pathways RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody (ABIN969231) Figure 1: Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and neg...
Image no. 2 for anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody (ABIN969231) Figure 2: Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells...
Image no. 3 for anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody (ABIN969231) Figure 3: Western blot analysis using KDR mouse mAb against extracellular domain of h...
Product cited in: Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).