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CREB1 antibody (N-Term)

CREB1 Reactivity: Human, Mouse, Rat WB, ELISA, GS Host: Rabbit Polyclonal unconjugated
Rockland
Catalog No. ABIN97864
Supplier Product No.: 100-401-195
  • Target See all CREB1 Antibodies
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Binding Specificity
    • 51
    • 27
    • 19
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 260
    • 197
    • 160
    • 33
    • 25
    • 20
    • 16
    • 15
    • 13
    • 10
    • 9
    • 8
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 235
    • 28
    • 1
    • 1
    Rabbit
    Clonality
    • 215
    • 50
    Polyclonal
    Conjugate
    • 136
    • 13
    • 10
    • 9
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    This CREB1 antibody is un-conjugated
    Application
    • 210
    • 88
    • 85
    • 72
    • 56
    • 56
    • 41
    • 36
    • 17
    • 16
    • 15
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Gel Shift (GS)
    Supplier Product No.
    100-401-195
    Supplier
    Rockland
    Purpose
    CREB-1 Antibody
    Characteristics
    Synonyms: rabbit anti-CREB1 Antibody, rabbit anti-p43 antibody, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1, CREB-1, CREB1, p43
    Purification
    Anti-CREB-1 was prepared from monospecific antiserum by delipidation and immunoadsorption against an E.coli lysate immobilized on agarose beads.
    Sterility
    Sterile filtered
    Immunogen

    Immunogen: CREB-1 (p43) peptide corresponding to a region near the N-terminus of the human protein, conjugated to Keyhole Limpet Hemocyanin (KLH).

    Immunogen Type: Conjugated Peptide

    Top Product
    Discover our top product CREB1 Primary Antibody
  • Application Notes

    Gel Shift Dilution: 0.5 to 1.0 μLper assay

    Application Note: Anti-CREB-1 Antibody has been tested in western blot and suitable in ELISA assays. Specific conditions for reactivity should be optimized by the end user.

    Western Blot Dilution: 1:500 - 1:1,000

    ELISA Dilution: 1:5,000 - 1:25,000

    Other: User Optimized

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.56 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Chen, Garvin, Nickola, Watson, Colberg-Poley, Rose: "IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 8, pp. L797-807, (2014) (PubMed).

    Wierda, Kuipers, van Eggermond, Benard, van Leeuwen, Carluccio, Geutskens, Jukema, Marquez, Quax, van den Elsen: "Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors." in: Journal of cellular and molecular medicine, Vol. 16, Issue 8, pp. 1866-77, (2012) (PubMed).

    Wang, Sasaki, Zhou, Matsumura, Araki, Mezawa, Takai, Chen, Ogata: "Transcriptional regulation of bone sialoprotein gene by interleukin-11." in: Gene, (2011) (PubMed).

    Philp, Chen, Lan, Meyer, Murphy, Knapp, Olfert, McCurdy, Marcotte, Hogan, Baar, Schenk et al.: "Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following ..." in: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30561-70, (2011) (PubMed).

  • Target
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Alternative Name
    CREB1 (CREB1 Products)
    Background
    Background: Anti CREB-1 Antibody recognizes CREB (cAMP response element-binding), a cellular transcription factor. CREB binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase, and many neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain.
    Gene ID
    1385
    UniProt
    P16220
    Pathways
    TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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