CREB1 antibody (cAMP Responsive Element Binding Protein 1) (N-Term)

Details for Product anti-CREB1 Antibody No. ABIN97864
Antigen
Epitope
N-Term
124
45
40
30
20
18
16
15
11
9
9
9
8
7
6
6
5
5
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
575
359
325
42
35
32
32
26
23
17
16
14
13
6
6
6
2
1
1
1
1
Host
Rabbit
510
72
7
1
Clonality
Polyclonal
Conjugate
This CREB1 antibody is un-conjugated
26
15
15
14
13
13
13
13
13
8
7
6
3
3
3
3
3
1
Application
Western Blotting (WB)
436
237
225
91
89
51
46
44
24
14
11
10
4
4
2
2
1
1
Options
Immunogen CREB-1 (p43) peptide corresponding to a region near the of the human protein, conjugated to Keyhole Limpet Hemocyanin (KLH).
Characteristics Concentration Definition: by UV absorbance at 280 nm
Antigen
Alternative Name CREB-1 (CREB1 Antibody Abstract)
Background Anti CREB-1 Antibody recognizes CREB (cAMP response element-binding), a cellular transcription factor. CREB binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase, and many neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain.
Synonyms: Cyclic AMP-responsive element-binding protein 1 cAMP-responsive element-binding protein 1 CREB-1 CREB1
Gene ID 1385
UniProt P16220
Pathways TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
Application Notes This product was assayed against a lysate of 1 x 10^6 Raji B cells by immunoblot and found to be reactive against CREB-1 (p43), showing a 46 kDa band at a dilution of 1:500 to 1:1,000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG (H&L) [Goat] Anti-CREB-1 (p43) is suitable for detection by immunoblot of human, mouse and rat CREB-1 (p43). This product was also tested in a gel supershift assay and found to be reactive against CREB-1 (p43) using 0.5 to 1.0 µl per assay. 
Restrictions For Research Use only
Format Liquid
Concentration 2.56 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-cAMP Responsive Element Binding Protein 1 (CREB1) (N-Term) antibody (ABIN97864) Anti-CREB is shown to detect CREB-1 present in Raji B cell nuclear extract. Detection...
Product cited in: Chen, Garvin, Nickola, Watson, Colberg-Poley, Rose: "IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 8, pp. L797-807, 2014 (PubMed).

Wang, Sasaki, Zhou, Matsumura, Araki, Mezawa, Takai, Chen, Ogata: "Transcriptional regulation of bone sialoprotein gene by interleukin-11." in: Gene, 2011 (PubMed).

Philp, Chen, Lan, Meyer, Murphy, Knapp, Olfert, McCurdy, Marcotte, Hogan, Baar, Schenk et al.: "Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following ..." in: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30561-70, 2011 (PubMed).