Glycogen Synthase 1 antibody (Glycogen Synthase 1 (Muscle)) (pSer640)

Details for Product anti-GYS1 Antibody No. ABIN99926
Antigen
Epitope
pSer640
14
10
8
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
88
61
48
8
7
6
1
1
1
Host
Rabbit
81
7
Clonality
Polyclonal
Conjugate
This Glycogen Synthase 1 antibody is un-conjugated
3
3
3
3
3
3
3
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
72
43
28
12
11
10
6
2
2
2
1
Options
Immunogen Human Muscle Glycogen Synthase phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Antigen
Alternative Name Glycogen Synthase 1 (GYS1 Antibody Abstract)
Background Anti-Glycogen synthase 1 pS640 is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units.  Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000.  GS is subject to regulation through both allosteric and covalent modification and occurs in two forms:  the phosphorylated inactive form, and the dephos-phorylated active form.  GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phos-phorylate muscle glycogen synthase.  This antibody is specific for the phosphorylated form of GS at S640.   Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.
Synonyms: Glycogen antibody, Glycogen synthase 1 (muscle) antibody, Glycogen synthase 1 antibody, Glycogen synthase1 antibody, GSY antibody, GYS 1 antibody, GYS antibody, GYS1 antibody, Starchsynthase muscle antibody
Gene ID 2997
UniProt P13807
Pathways PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process
Application Notes This phospho specific polyclonal antibody was tested by immunoblotting and ELISA.  By ELISA the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide.   Immunoblotting will detect human and mouse muscle glycogen synthase.  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Glycogen Synthase 1 (Muscle) (GYS1) (pSer640) antibody (ABIN99926) Affinity Purified Phospho-specific antibody to human muscle Glycogen Synthase (GS) at...
Image no. 2 for anti-Glycogen Synthase 1 (Muscle) (GYS1) (pSer640) antibody (ABIN99926) Affinity Purified Phospho-specific antibody to human muscle Glycogen Synthase (GS) at...
Image no. 3 for anti-Glycogen Synthase 1 (Muscle) (GYS1) (pSer640) antibody (ABIN99926) Immunohistochemistry with Anti-Glycogen Synthase antibody Tissue: Human Prostate Fixa...