Glycogen Synthase 1 antibody (pSer640)

Catalog No. ABIN99926

Product Details anti-Glycogen Synthase 1 Antibody

Target: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Binding Specificity: pSer640

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glycogen Synthase 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: Human Muscle Glycogen Synthase phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).

Isotype: IgG

Application Details

Application Notes: This phospho specific polyclonal antibody was tested by immunoblotting and ELISA.  By ELISA the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide.   Immunoblotting will detect human and mouse muscle glycogen synthase.  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Glycogen Synthase 1

Target: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Alternative Name: Glycogen Synthase 1 (GYS1 Products)

Synonyms: GSY antibody, GYS antibody, GYS1 antibody, zgc:63701 antibody, GYS2 antibody, Gys3 antibody, MGS antibody, glycogen synthase 1 antibody, glycogen synthase 1 (muscle) antibody, glycogen synthase 1, muscle antibody, GYS1 antibody, gys1 antibody, Gys1 antibody

Background: Anti-Glycogen synthase 1 pS640 is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units.  Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000.  GS is subject to regulation through both allosteric and covalent modification and occurs in two forms:  the phosphorylated inactive form, and the dephos-phorylated active form.  GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phos-phorylate muscle glycogen synthase.  This antibody is specific for the phosphorylated form of GS at S640.   Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.
Synonyms: Glycogen antibody, Glycogen synthase 1 (muscle) antibody, Glycogen synthase 1 antibody, Glycogen synthase1 antibody, GSY antibody, GYS 1 antibody, GYS antibody, GYS1 antibody, Starchsynthase muscle antibody

Gene ID: 2997

UniProt: P13807

Pathways: PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process