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BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma.
inhibition of the BCL2 family member BCLxL resulted in nanomolar potency against human synovial sarcoma cell lines and 50% tumor reduction in a genetically engineered mouse model
In this study, we investigated whether APG (show SMAD1 Proteins)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (show TIMM8A Proteins) assay.APG-1252-12A is a Bcl-2 (show BCL2 Proteins) homology (BH)-3 mimetic that specifically binds to Bcl-2 (show BCL2 Proteins) and Bcl-xl, which has shown efficacy in some Bcl-2 (show BCL2 Proteins) dependent hematological cancers
inhibition of Bcl-xL induces significantly more apoptosis in IDH1 (show IDH1 Proteins)-mutated cells than in wild-type IDH1 (show IDH1 Proteins) cells.
CCAT1 is upregulated in docetaxel-resistant lung adenocarcinoma cells; its oncogenic function depends on sponging of let-7c, which releases Bcl-xl, promoting the acquisition of chemoresistance and epithelial-to-mesenchymal transition phenotypes
In the epithelial ovarian cancer stem cells, 40% knock-down of Bclxl expression was sufficient to induce the full activation of caspases. Bclxl expression levels in EOC cells is dynamic and can be regulated by microenvironments that are enriched with the pro-inflammatory cytokine IL-6 (show IL6 Proteins) such as the cancer stem cell and adipocyte niches.
Study reports the interaction of BCL-XL with RASSF6 (show RASSF6 Proteins). BCL-XL inhibits the interaction between RASSF6 (show RASSF6 Proteins) and MDM2 (show MDM2 Proteins) and suppresses p53 (show TP53 Proteins) expression. Consequently, BCL-XL antagonizes RASSF6 (show RASSF6 Proteins)-mediated apoptosis. Thus, the inhibition of RASSF6 (show RASSF6 Proteins)-mediated apoptosis also underlies the prosurvival role of BCL-XL.
anti-apoptotic molecules BclxL and Bcl-2 (show BCL2 Proteins) and the pro-apoptotic factors BAD and BID (show BID Proteins) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (show FASL Proteins).
These results show that mRNA expression in centenarians is unique and reveals that Bcl-xL plays an important role in exceptional aging.
that Ubiquitin-specific peptidase 18 (show USP18 Proteins) directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells
targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling.
GATA-3 (show GATA3 Proteins) participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2 (show RUNX2 Proteins).
this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl
Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway.
Proapoptotic proteins BIM (show BCL2L11 Proteins) and PUMA (show BBC3 Proteins) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
BMP4 (show BMP4 Proteins) promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4 (show BMP4 Proteins)-Smad1 (show SMAD1 Proteins)/5/8-Id1 (show ID1 Proteins) signaling in the presence of FGF-2 (show FGF2 Proteins).
We propose that the GC-induced mitochondrial accumulation of Bax (show BAX Proteins) and the interaction between the GR and Bim (show BCL2L11 Proteins), Bcl-xL and Bak (show BAK1 Proteins) could play a role in the regulation of thymocyte apoptosis.
Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord.
amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
interleukin-6 (show IL6 Proteins), endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Proteins) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.
Bcl-Xl deamidation and methylation has a role in protein isoaspartate methyltransferase prevention of apoptosis induced by oxidative stress in endothelial cells
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1.
This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
repression of radiation-induced apoptosis by overexpression of Bcl-xL during embryonic development depends upon the timing of its expression and post-translational events that enable the protein to become effective
The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Delta113p53 functions to antagonize p53 (show TP53 Proteins)-induced apoptosis via activating bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
apoptosis regulator Bcl-X
, bcl-2-like protein 1
, protein phosphatase 1, regulatory subunit 52
, B-cell leukemia/lymphoma x
, anti-apoptosis regulatory protein
, B cell lymphoma 2 like
, B cell lymphoma like X
, BCL2-like protein 1
, anti-apoptotic Bcl-xL
, BCLX protein
, BCL2-like 1
, apoptosis regulator R11
, Bcl-xL-like protein 1