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anti-Mouse (Murine) Caspase 12 Antibodies:
anti-Rat (Rattus) Caspase 12 Antibodies:
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Mouse (Murine) Polyclonal Caspase 12 Primary Antibody for IF (p), IHC (p) - ABIN737736
Zhang, Lv, Zhao, Jia, Zhang, Xiao, Wang, Li, Ji, Tian, Li, Fan, Lai, Liu, Li, Zhang, Liu, Guo, Han, Ji: Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome. in Gene 2014
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Mouse (Murine) Polyclonal Caspase 12 Primary Antibody for WB - ABIN223032
Chin, Lin, Kuo, Chueh: Dual effect of thapsigargin on cell death in porcine aortic smooth muscle cells. in American journal of physiology. Cell physiology 2007
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Human Polyclonal Caspase 12 Primary Antibody for - ABIN549152
Huang, Haataja, Gurlo, Butler, Wu, Soeller, Butler: Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. in American journal of physiology. Endocrinology and metabolism 2007
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Human Polyclonal Caspase 12 Primary Antibody for IHC (p), WB - ABIN3042658
Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect. in PLoS ONE 2011
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Human Polyclonal Caspase 12 Primary Antibody for - ABIN550325
Van de Craen, Vandenabeele, Declercq, Van den Brande, Van Loo, Molemans, Schotte, Van Criekinge, Beyaert, Fiers: Characterization of seven murine caspase family members. in FEBS letters 1997
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Human Polyclonal Caspase 12 Primary Antibody for IHC (p), WB - ABIN541406
Mehmet: Caspases find a new place to hide. in Nature 2000
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Human Polyclonal Caspase 12 Primary Antibody for IHC (p) - ABIN541218
Nakagawa, Zhu, Morishima, Li, Xu, Yankner, Yuan: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. in Nature 2000
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Human Polyclonal Caspase 12 Primary Antibody for ELISA, ICC - ABIN4288054
Nakagawa, Yuan: Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. in The Journal of cell biology 2000
Human Polyclonal Caspase 12 Primary Antibody for ELISA, WB - ABIN4288058
Lee, Lee, Park, Sharoar, Shin, Lee, Cho, Park: Purification of catalytically active caspase-12 and its biochemical characterization. in Archives of biochemistry and biophysics 2010
mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Caspase-12 plays a pivotal role in CCl4-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via caspase-9 activation.
We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin-deficient mdx mouse, the model for Duchenne muscular dystrophy.
Tauroursodeoxycholic acid intervention down-regulated GRP78 and CHOP expression and Caspase 12 activation.
Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection.
caspase-12 competed with NEMO for association with IkappaB kinase-alpha/beta, effectively preventing the formation of the IkappaB kinase complex and inhibiting downstream transcriptional activation by NF-kappaB.
Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25-mediated ubiquitination of RIG-I. .
Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy.
enhanced repair response of Casp12(-/-) mice rendered them more susceptible to colorectal cancer induced by azoxymethane (AOM)+ dextran sulfate sodium.
role of caspase-12-dependent pathway in apoptosis induction by manganese(II)
caspase-12 was activated by poly(Q)(72) aggregates via a pathway independent of caspase-8 and caspase-3 activation, and caspase-12 activation was closely associated with poly(Q) aggregate-mediated cell death
procaspase-9 is a substrate of caspase-12 and ER stress triggers a specific cascade involving caspase-12, -9, and -3 in a cytochrome c-independent manner.
Caspase-12 seems to be involved in neuronal death induced by ischemia/reperfusion.
Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion disorders.
caspase-12 expression in caspase-12 is regulated by NF-E2 and participates in the development of fully functional signaling pathways linking some G-protein-coupled receptors to alphaIIbbeta3 activation.
both caspases and calpains are involved in 661W photoreceptor apoptosis
The results indicate that oxidative and ER induced stress causing caspase-12 activation are involved in neuronal death and disease progression in ALS.
Piezo1 plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12-dependent pathway.
study indicated the potential effect of Casp12 was on the activation of NF-kappaB by the degradation of IkappaBalpha in NPC cells.
CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans
Endoplasmic reticulum stress may be associated with apoptosis of LECs, resulting in cataract formation in diabetic patients.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.
We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression
conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP
EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.
Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.
CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.
examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product
caspase 12 has acquired deleterious mutations
Na/Ca exchanger overexpression activates caspase-12
Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis
The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced.
proteolytic activity of caspase-12 is confined to its own proenzyme
hRPE cells express a high level of caspase-12S. The regulated expression of caspase-12S suggests that this caspase recruitment domain (CARD)-only protein may be an endogenous dominant negative regulator that modulates inflammatory responses in hRPE cells.
estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from Listeria monocytogenes infection.
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
, caspase 12 pseudogene 1
, inactive caspase-12