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anti-Human CYLD Antibodies:
anti-Mouse (Murine) CYLD Antibodies:
anti-Rat (Rattus) CYLD Antibodies:
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Mouse (Murine) Polyclonal CYLD Primary Antibody for ELISA, WB - ABIN188848
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. in Cell 2006
Cow (Bovine) Polyclonal CYLD Primary Antibody for ICC, IF - ABIN410065
Wu, Mu, Gao, Wang, Sy, Li: Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. in The Journal of biological chemistry 1970
Human Polyclonal CYLD Primary Antibody for ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. in Infection and immunity 2010
Polyclonal CYLD Primary Antibody for WB - ABIN540750
Hellerbrand, Bumes, Bataille, Dietmaier, Massoumi, Bosserhoff: Reduced expression of CYLD in human colon and hepatocellular carcinomas. in Carcinogenesis 2006
CYLD inhibits post-transcriptional regulation of RIG-I (show DDX58 Antibodies) and MDA5 (show IFIH1 Antibodies) expression following TLR3 (show TLR3 Antibodies) activation in MCs (show SMCP Antibodies). CYLD may be involved in the pathogenesis of CKD
miR (show MLXIP Antibodies)-197-3p-induced downregulation of CYLD promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.
Knockdown of CYLD expression reversed the cell proliferation promotion by miR1288in in glioblastoma.
TNF (show TNF Antibodies) phase III signalling displays ongoing TNFR1 (show TNFRSF1A Antibodies)/NF-kappa B (show NFKB1 Antibodies) activation in monocytic cells. High- and low-sensitive genes are induced including differentially regulated A20 (show TNFAIP3 Antibodies). A20 (show TNFAIP3 Antibodies) strictly controls this signalling in an IKK (show CHUK Antibodies)- and partially RIP (show HRB Antibodies)-dependent manner. The A20 (show TNFAIP3 Antibodies)-mediated control mechanisms are supported by ABIN1 (show TNIP1 Antibodies) and CYLD.
Low expression of CYLD is associated with glioma.
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (show EGFR Antibodies) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (show EGFR Antibodies) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (show NFKB1 Antibodies) signaling, miR (show MLXIP Antibodies)-130b can in return sustain the persistent activation of NF-kappaB (show NFKB1 Antibodies), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (show F2 Antibodies)-mediated MALT1 (show MALT1 Antibodies) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (show MLXIP Antibodies)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
Loss of CYLD catalytic activity causes impaired DNA damage-induced p53 (show TP53 Antibodies) stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis.
The present results support the involvement of CYLD in the regulation of NF-kappaB (show NFKB1 Antibodies) inflammatory signaling induced by elevated glucose, implicating CYLD as a potential therapeutic target of diabetic nephropathy .
the role of CYLD in development, tissue homeostasis, and tumorigenesis
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (show HDAC6 Antibodies) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
SPATA2 (show SPATA2 Antibodies) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (show RNF31 Antibodies) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
TLR4 (show TLR4 Antibodies) activates CASPASE-8 (show CASP8 Antibodies) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (show RNF138 Antibodies)- and RIPK1 (show RIPK1 Antibodies)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (show NOX4 Antibodies) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 Antibodies)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 Antibodies)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog