CYLD antibody (AA 305-582)

Catalog No. ABIN6242844

The Mouse Monoclonal anti-CYLD antibody is suitable to detect CYLD in samples from Human. It has been validated for WB and FACS.

Quick Overview for CYLD antibody (AA 305-582) (ABIN6242844)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYLD antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 1667CT857-3-6-1

Product Details anti-CYLD Antibody

Binding Specificity: AA 305-582

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD.

Isotype: IgG2a kappa

Application Details

Application Notes: WB: 1:4000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD

Background: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917689" target="_blank">12917689, PubMed:< a href="http://www.uniprot.org/citations/12917691" target="_blank">12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917690" target="_blank">12917690). Negative regulator of Wnt signaling (PubMed:< a href="http://www.uniprot.org/citations/20227366" target="_blank">20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:< a href="http://www.uniprot.org/citations/18222923" target="_blank">18222923, PubMed:< a href="http://www.uniprot.org/citations/20194890" target="_blank">20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:< a href="http://www.uniprot.org/citations/17495026" target="_blank">17495026, PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/18636086" target="_blank">18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity).

Molecular Weight: 107316

UniProt: Q9NQC7

Pathways: Apoptosis, Activation of Innate immune Response