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anti-Human Cytochrome C Antibodies:
anti-Mouse (Murine) Cytochrome C Antibodies:
anti-Rat (Rattus) Cytochrome C Antibodies:
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Dog (Canine) Monoclonal Cytochrome C Primary Antibody for ICC, FACS - ABIN252468
Eid, Lewis, Kumar: Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL). in Molecular cancer therapeutics 2002
Show all 44 Pubmed References
Dog (Canine) Monoclonal Cytochrome C Primary Antibody for IHC (fro), IHC - ABIN251788
Pervaiz, Seyed, Hirpara, Clément, Loh: Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. in Blood 1999
Show all 32 Pubmed References
Human Polyclonal Cytochrome C Primary Antibody for IF (cc), IF (p) - ABIN723590
Wang, Wang, Shan, Song, Dai, Wang, Chi: Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus. in Brain research bulletin 2008
Show all 14 Pubmed References
Human Monoclonal Cytochrome C Primary Antibody for WB - ABIN222881
Ahmed, Alcock, Chendil, Dey, Das, Venkatasubbarao, Mohiuddin, Sun, Strodel, Freeman: Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2. in The Journal of biological chemistry 2002
Show all 12 Pubmed References
Chicken Polyclonal Cytochrome C Primary Antibody for IP, WB - ABIN222880
Kuhn, Chen, Voorhees, Strader, Shenk, Sun, Demo, Bennett, van Leeuwen, Chanan-Khan, Orlowski: Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. in Blood 2007
Show all 10 Pubmed References
Human Polyclonal Cytochrome C Primary Antibody for ICC, IHC (fro) - ABIN3043697
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 10 Pubmed References
Human Polyclonal Cytochrome C Primary Antibody for ICC, IHC (p) - ABIN3042783
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy. in Neural regeneration research 2015
Show all 10 Pubmed References
Rat (Rattus) Polyclonal Cytochrome C Primary Antibody for WB - ABIN223076
Machiya, Shibata, Yamauchi, Hirama, Wada, Inoue, Abe, Takabatake, Sata, Kubota: Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure. in American journal of respiratory cell and molecular biology 2007
Show all 8 Pubmed References
Human Monoclonal Cytochrome C Primary Antibody for BP, IHC (fro) - ABIN4301951
Chan, Wu, Yu: Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. in Journal of cellular biochemistry 2003
Show all 6 Pubmed References
Cow (Bovine) Polyclonal Cytochrome C Primary Antibody for WB - ABIN223077
Zhao, Chen, Lu, Dong, Wang, Bi, Wu, Guo, Wu, Guo: TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma. in Cancer research 2008
Show all 4 Pubmed References
The naturally occurring Y48H variant of cytochrome c in its oxidized heme state is more peroxidatic than either the Wild Type protein or the G41S variant that is also implicated in thrombocytopenia.
ROCK activation phosphorylated Rac1b (show RAC3 Antibodies) at Ser71 and increased reactive oxygen species (ROS (show ROS1 Antibodies)) levels by facilitating the interaction between Rac1b (show RAC3 Antibodies) and cytochrome c. Conversely, ROCK inactivation abolished their interaction, concomitant with ROS (show ROS1 Antibodies) reduction.
Data suggest that although HCCS (show HCCS Antibodies) mediates heme attachment to N-terminal cysteine in heme-attachment site (CXXXH) of cytochrome C variants, up to 50% of cytochrome C produced is modified in an oxygen-dependent manner, resulting in a mixed population of cytochrome c. [HCCS (show HCCS Antibodies) = holocytochrome c synthase (show HCCS Antibodies)]
Data suggest that the stronger effect of K72A mutation on the peroxidase activity of human versus yeast cytochrome c results from relief of steric interactions between side chains at positions 72 and 81 (Ile in human vs Ala in yeast), which suppresses the dynamics of omega-loop D necessary for the intrinsic peroxidase activity of cytochrome c.
These findings establish a framework for understanding the molecular basis of cytochrome c-mediated blocking of SET/TAF-Ibeta.
Monitoring of serum cytochrome c might also serve as a sensitive apoptotic marker in vivo reflecting chemotherapy-induced cell death burden in patients with non-small cell lung cancer.
G-Rh2 (show RHAG Antibodies) causes rapid and dramatic translocation of both Bak (show BAK1 Antibodies) and Bax (show BAX Antibodies), which subsequently triggers mitochondrial cytochrome c release and consequent caspase (show CASP3 Antibodies) activation.
The mitochondrial metalloprotease OMA1 (show OMA1 Antibodies) was activated in a Bax (show BAX Antibodies)- and Bak (show BAK1 Antibodies)-dependent fashion.
In vitro ultrastructural changes of MCF-7 for metastasise bone cancer and induction of apoptosis via mitochondrial cytochrome C released by CaCO3/Dox nanocrystals
a mechanism of multiple radical formations in the cytochrome c-phospholipid complexes under H2O2 treatment, consistent with the stabilization of the radical in the G41S mutant, which elicits a greater peroxidase activity from cytochrome c
Results suggest that excess or restricted protein supply during pregnancy alters expression of CYCS and leads to hypomethylation of CpG sites in promoter in liver of offspring. (5' flanking region: amino acid sequence; nucleic acid sequence homology)
Tissue expression profile analysis revealed that swine CYCS gene was highly expressed in muscle, fat and lung, moderately expressed in ovary, kidney, and liver, and weekly expressed in heart, spleen and small intestine.
Using mass spectrometry, this study demonstrates the occurrence of cytochrome c self-oxidation in the presence of H2O2. The newly generated oxidized proteoforms are shown to possess significantly enhanced peroxidase activity.
Cytochrome c undergoes large structural fluctuations, using the interacting regions with cytochrome c oxidase as a fulcrum.
Data suggest that ferric forms of variants of cytochrome c (wild type, T49V mutation, and Y67R/M80A mutations) are Lysine-ligated at neutral pH; hydrogen-bonding network appears to be important in controlling ligation of the native Met80 to the heme iron.
analysis of CO photo-dissociation from chloramine-T modified horse heart cytochrome-c
The effect of pH on thermodynamic stability and folding kinetics of horse cytochrome c has been described.
The cardiolipin binding and the peroxidase activity of cytochrome c depend on conformational heterogeneity and oligomerization.
The data suggest a two-step process of thermal unfolding of cytochrome c for all protonation states.
The study shows that cardiolipin modulates allosterically the nitrite reductase activity of horse heart cytochrome c.
Horse Cc binds CcP (show CRYGD Antibodies) but forms a much more dynamic complex. A single conservative mutation of Lys (show LYZ Antibodies)-13 to ARG reduces the dynamics and enhances the specificity. The K13A mutation of Cc increases the dynamic nature of the complex with CcP (show CRYGD Antibodies).
X-ray crystallographic evidence for functional models of horse cytochrome c.
This study determines the apoptosis process mediated by cytochrome c after its release from mitochondria and the factors that affect the activation processes.
Data using ribose 5-P suggest that glycation of cyt c (at lysines in ATP binding site) results in cyto c being less able to transfer electrons to cytochrome oxidase and in reduced affinity of cyt c for cardiolipin-containing liposomes.
The presence of structural collective motions on a picosecond timescale for the heme protein, cytochrome c, as a function of oxidation and hydration, was investigated.
peroxidase activity shown by cardiolipin-bound cytochrome c is indicative of a less packed protein tertiary conformation in the complex
the amount of cytochrome c in lymphomyeloid cells does not affect their development and normal functioning
Abeta (show APP Antibodies) oligomers bind to BAK (show BAK1 Antibodies) on the membrane and induce apoptotic BAK (show BAK1 Antibodies) pores and cytochrome c release
Data suggest that peroxidase activation of cytochrome c may induce apoptosis and contribute to anti-cancer properties of alpha-tocopherol succinate.
Data indicate that mitochondrial alpha 7 nicotinic acetylcholine receptors (alpha7 nAChRs) regulate cytochrome c (cyt c) release by engaging intramitochondrial protein kinases.
Data indicate that Y48H missense mutation of cytochrome c (CYCS) gene is associated with respiratory reduction and increased apoptosis in fibroblast.
Translocation of a Bak (show BAK1 Antibodies) C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak (show BAK1 Antibodies) and Bax (show BAX Antibodies) apoptotic function.
mitochondrial import and direct electron transfer from cytochrome c to Rac1 modulates mitochondrial H(2)O(2) production in alveolar macrophages pulmonary fibrosis.
Fluoride exposure significantly elevated the protein expressions of cytochrome c and active caspase-3 (show CASP3 Antibodies).
Resveratrol induces p53 (show TP53 Antibodies)-independent, X-linked inhibitor of apoptosis protein (XIAP (show XIAP Antibodies))-mediated Bax (show BAX Antibodies) protein oligomerization on mitochondria to initiate cytochrome c release and caspase (show CASP3 Antibodies) activation.
High concentration glucose administration caused significantly increased expression of NF-kappaB (show NFKB1 Antibodies), Bax (show BAX Antibodies) and cytochrome C.
results reveal Blanks to be a unique component of a nuclear siRNA/dsRNA-binding complex that contributes to essential RNA silencing-related pathways in the male germ line
We further identified loss-of-function mutations in one of the two Drosophila cyt-c genes, cyt-c-d, which block caspase (show CASP3 Antibodies) activation and subsequent spermatid terminal differentiation.
DARK-mediated DRONC activation occurs independently of Cyt-c-p
We found that cyt c-d--as with ark (show APAF1 Antibodies) and dronc-regulates scutellar bristle number, which is known to depend on caspase (show CASP3 Antibodies) activity. Collectively, our results indicate a role of Cyt c in caspase (show CASP3 Antibodies) regulation of Drosophila somatic cells.
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.
, cytochrome c, testis-specific
, cytochrome c, testis
, somatic cytochrome c
, cytochrome c, somatic
, Cytochrome C, expressed in somatic tissues
, cytochrome c distal
, cytochrome c DC4
, cytochrome c proximal
, Cytochrome c
, cytochrome c, somatic pseudogene