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K18 deficiency of hepatocytes leads to steatosis, increasing with age, and finally to SH. K18 deficiency and age promote liver tumor development in mice, frequently on the basis of chromosomal instability, resembling human HCC (show FAM126A Proteins) with stemness features.
K8/K18-dependent PKCdelta (show PKCd Proteins)- and ASMase (show SMPD1 Proteins)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 loss.
autoantibodies were detected in aging K18-null male mice that had a related liver phenotype but normal colon compared with K8-null mice, suggesting that the autoantibodies are linked to liver rather than colonic disease
In human failing myocardium, where TNF-alpha (show TNF Proteins) expression is upregulated, K8/K18 were also ectopically expressed
The findings demonstrate the near complete loss of K8/K18 with concomitant high levels of vimentin (show VIM Proteins) in CT26 (show DDX53 Proteins) cells, a chemically-induced mouse colonic tumor.
in contrast to its importance as luminal cell marker, CK18 is dispensable for the prostate morphogenesis but contributes to adult prostate regeneration
Keratin 18 increases CFTR (show CFTR Proteins) expression by binding to its C-terminal hydrophobic domain.
Oxidative stress, Nrf2 (show NFE2L2 Proteins) and keratin 18 up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria (show FECH Proteins)
Keratin 8 (show KRT8 Proteins) and keratin 18 mice on the same genetic background show similar sensitivity to DDC (show DDC Proteins) intoxication.
These findings reveal the potential for cytokeratin 18 to be used as a diagnostic marker for early detection of hepatosplenic schistosomiasis.
This study analyzed phase III data comparing basal insulin peglispro (BIL) and insulin glargine in type 1 (T1D), and type 2 diabetes (T2D) (insulin-naive and insulin-treated). Alanine aminotransferase (ALT), K-18, enhanced liver fibrosis scores and liver fat content.
Results found that CK18, MMP-9 (show MMP9 Proteins), and TIMP1 (show TIMP1 Proteins) averages of those with positive clinical lymph nodes and those in clinical stage 3 were higher than the averages of those with negative clinical lymph nodes and those in clinical stage 2.
Plasma M30-M65 levels are higher in serum of patients with placental abruption.
results show that the caspase digestion-resistant K18 helps to maintain keratin filament organization and delays apoptosis, thereby resulting in protection from liver injury.
K8/K18 variants are overrepresented in Chinese NAFLD patients and might accelerate liver fat storage through insulin (show INS Proteins) resistance.
The plasma keratin-18 (K18) values of nonsurviving alcoholic hepatitis (AH) patients were significantly elevated above their surviving counterparts and healthy controls
Evidence suggested that the modification of histone H3 (show HIST3H3 Proteins) was highly correlated with the modulation of cytokeratin 18 and probably plays an important role in tumorigenesis of hepatocytes
K8/K18 interact with Notch1 (show NOTCH1 Proteins) and regulate Notch1 (show NOTCH1 Proteins) signalling activity during differentiation of the colonic epithelium.
FIB (show FBL Proteins)-4 index and CK-18F have good diagnostic abilities not only for nonalcoholic steatohepatitis (NASH (show SAMSN1 Proteins)) overall, but also for NASH (show SAMSN1 Proteins) with mild fibrosis.
In children with nonalcoholic fatty liver disease, CK18 levels were found to be significantly higher in subjects with any fibrosis compared with those without fibrosis (304.6 +/- 124.8 vs 210.4 +/- 70.9, P < 0.001).
Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.
krt18 is maternally inherited and its tissue distribution is reported. Its expression is established during early embryogenesis.
Ezrin (show EZR Proteins) and CK18 are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy.
Results did not support that K8/K18 filaments influence the expression of Fas (show FAS Proteins) on the surface of luteal cells.
Data indicate that CK18 may be a molecular marker for bovine M cells in follicule-associated epithelium of Peyer's patches.
KRT18 knockdown in preimplantation embryos results in reduced blastocyst formation, but no further morphological aberrations were observed with regard to the biological function of KRT18.
Mechanical injury of vascular smooth muscle up-regulated keratin 18.
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
, Endo B
, cytokeratin endo B
, keratin D
, keratin complex 1, acidic, gene 18
, keratin, type I cytoskeletal 18
, cell proliferation-inducing gene 46 protein
, cell proliferation-inducing protein 46
, cytokeratin 18
, dorsal aorta proneprin kinesin-1
, keratin 18
, simple type I keratin
, Keratin, type I cytoskeletal 18
, keratin, type I cytoskeletal 18-like
, keratin 18, type I