Browse our Perforin 1 Proteins (PRF1)

Full name:: Perforin 1 (Pore Forming Protein) Proteins (PRF1)

On www.antibodies-online.com are 15 Perforin 1 (Pore Forming Protein) (PRF1) Proteins from 6 different suppliers available. Additionally we are shipping Perforin 1 Antibodies (201) and Perforin 1 Kits (103) and many more products for this protein. A total of 329 Perforin 1 products are currently listed.

Synonyms:: Cyta, cytolysin, FLH2, HPLH2, LOC443187, P1, perforin, perforin-1, perforin-1-like, Pfn, PFN1, Pfp, Prf-1, prf1, RATCYTA

list all proteins	Gene Name	GeneID	UniProt
	PRF1	5551	P14222
	PRF1	18646	P10820
	PRF1	50669
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Human Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

Perforin binds to membranes and undergoes substantial structural re-arrangement to form pores that enable diffusion of granzyme into the target cell [Review].
findings show that N-linked glycosylation of the perforin C-terminus at Asn549 within the endoplasmic reticulum inhibits oligomerisation of perforin monomers and protects the host cell from premature pore formation; studies reveal a post-translational regulatory mechanism essential for maintaining perforin in an inactive state until its secretion from the inhibitory acidic environment of the secretory granule
Study focuses on the role of perforin in both protecting and promoting human disease. It concludes with a novel hypothesis that diversity observed in the PRF1 gene may be an example of selective advantage that protects an individual from perforin-mediated pathology, such as blood-brain barrier disruption. [review]
Our studies suggest that although moderate levels of expression can result in partial amelioration of the hemophagocytic lymphohistiocytosis (HLH)phenotype, high levels of perforin expression per cell are required for complete correction of HLH.
Findings support an association between childhood DNA methylation (show HELLS Proteins) patterns in PRF1 and a record of severe respiratory syncytial virus bronchiolitis in infancy.
our data provide the first evidence of a strict link between the absence of CD28 (show CD28 Proteins) and the expression of perforin, which is likewise enhanced by the expression of NKG2D (show KLRK1 Proteins), within selected CD4 (show CD4 Proteins)(+) T cells from cervical cancer patients.
A girl with neurological manifestations of familial hemophagocytic lymphohistiocytosis 2 had reduced perforin 1 expression and was found to be homozygous for a mutation in PRF1 at codon 637 in exon 3 (c.673C>T p.Arg225Trp). Her non-consanguineous parents were both heterozygous carriers of this mutation.
Mutation in PRF1 gene is associated with hemophagocytic lymphohistiocytosis.
Increased TIM3 (show HAVCR2 Proteins)+CD8 (show CD8A Proteins)+T cells with lower perforin and granzyme B expression and higher CD95 (show FAS Proteins) expression in MDS (show PAFAH1B1 Proteins) patients were observed.
ITP (show ITPA Proteins) patients displayed an increased frequency of rare missense variations of the PRF1 gene

Mouse (Murine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

levetiracetam can still protect neurons with perforin knockout mice.
These studies indicate that CD8 (show CD8A Proteins)+ T cells against a single antigen can restrict Y. pseudotuberculosis colonization in a perforin-dependent manner, but ultimately are insufficient in their ability to provide sterilizing immunity and protect against death.
Furthermore, perforin production specifically by CD8 (show CD8A Proteins) T cells was required to cause fatal edema during experimental cerebral malaria.
Our study suggests that perforin plays a role in dopaminergic neuron loss in PD.
IL-18 (show IL18 Proteins)-elicited NK cell perforin responses seem to be critical for coordinating mucosal inflammation during early infection
study shows that perforin is essential to facilitate beta cell destruction in mouse models of type 1 diabetes
Released granzyme B induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin
serglycin (show SRGN Proteins) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B, whereas granzyme A (show GZMA Proteins) is unaffected
This suggests that LPS alters UNK cell migration and activates cytotoxic granule release.
it is proposed that Ca(2 (show CA2 Proteins)+) binding at the weakest affinity site triggers changes in the perforin C2 domain that facilitate its interaction with lipid membranes

Cow (Bovine) Perforin 1 (Pore Forming Protein) (PRF1) interaction partners

It is a cytotoxic genes in the endometrium and hightly expressed in the peri (show PLIN1 Proteins)-implantation endometrium.

Perforin 1 (PRF1) Protein Profile

Protein Summary

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with Perforin 1 (PRF1)

perforin 1 (PRF1)
perforin 1 (pore forming protein) (Prf1)
perforin 1 (Prf1)
perforin (LOC443187)
perforin (prf1)
perforin 1 L homeolog (prf1.L)

Cyta protein
cytolysin protein
FLH2 protein
HPLH2 protein
LOC443187 protein
P1 protein
perforin protein
perforin-1 protein
perforin-1-like protein
Pfn protein
PFN1 protein
Pfp protein
Prf-1 protein
prf1 protein
RATCYTA protein

Protein level used designations for PRF1

cytolysin , lymphocyte pore forming protein , lymphocyte pore-forming protein , perforin-1 , perforin 1 (pore forming protein) , perforin-1-like , P1 , pore forming protein , perforin , perforin 1 (pore forming protein) L homeolog , perforin 1 L homeolog

GENE ID	SPECIES
5551	Homo sapiens
450512	Pan troglodytes
489030	Canis lupus familiaris
100404817	Callithrix jacchus
100473675	Ailuropoda melanoleuca
18646	Mus musculus
50669	Rattus norvegicus
443187	Ovis aries
100113473	Felis catus
100136143	Oncorhynchus mykiss
396595	Sus scrofa
369025	Bos taurus
100730283	Cavia porcellus
100342396	Oryctolagus cuniculus
101750363	Gallus gallus
495232	Xenopus laevis

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