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By downregulating TRAIL-R1, TGFbeta1 (show TGFB1 Proteins) may not only promote tumor escape from immune surveillance but also negatively impact on TRAIL- or TRAIL-R1-based therapy regimens for treatment of Pancreatic ductal adenocarcinoma.
Results show that downregulation of DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) by SLC26A2 (show SLC26A2 Proteins) confers resistance to TRAIL.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (show HLADRB4 Proteins) expression in p53 (show TP53 Proteins)-dependent manner and inhibiting NF-kappaB (show NFKB1 Proteins) activity.
findings together highlight a previously undiscovered mechanism that positively regulates DR4 (show HLADRB4 Proteins) expression through activation of the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/AP-1 (show FOSB Proteins) signaling pathway.
results suggest that the altered TRAIL, DR4 (show HLADRB4 Proteins) alleles and sTRAIL levels may be associated with some other potential biomarkers for vitiligo (show MITF Proteins)
The nanovectorization of TRAIL enhanced its binding to both DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).
Pro-survival effects by NF-kappaB (show NFKB1 Proteins), Akt (show AKT1 Proteins) and ERK(1 (show MAPK3 Proteins)/2) and anti-apoptosis actions by Six1 (show SIX1 Proteins) disrupt apoptotic functions of TRAIL-Dr4 (show HLADRB4 Proteins)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Bee venom inhibits colon cancer cell growth, and these anti-proliferative effects may be related to the induction of apoptosis by activation of DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) and inhibition of NF-kappaB (show NFKB1 Proteins) activity.
study involving a relatively large sample size showed that TNFRSF10 eQTL (show EQTN Proteins) SNPs within lncRNAs might influence both hepatocellular carcinoma development and HBV infection
Study investigated the association between colorectal cancer and polymorphisms in TRAIL and DR4 (show HLADRB4 Proteins) gene in Pakistani patients; TRAIL gene 1595 C>T genotypes percentage in colorectal cancer patients was statistically non-significant; for DR4 (show HLADRB4 Proteins) A1322G, homozygous GG genotype was 36% in the patients and in controls: there was statistically insignificant difference (p> 0.05).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
TNF-related apoptosis-inducing ligand receptor 1
, TRAIL receptor 1
, cytotoxic TRAIL receptor
, death receptor 4
, tumor necrosis factor receptor superfamily member 10A
, tumor necrosis factor receptor superfamily member 10a variant 2
, tumor necrosis factor receptor superfamily, member 10a
, tumor necrosis factor receptor superfamily member 10A-like