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anti-Human TNFSF10 Antibodies:
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Human Monoclonal TNFSF10 Primary Antibody for IHC (p), WB - ABIN252480
Müller, Raftery, Kather, Giese, Schönrich: Frontline: Induction of apoptosis and modulation of c-FLIPL and p53 in immature dendritic cells infected with herpes simplex virus. in European journal of immunology 2004
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Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN2689127
Marsters, Pitti, Donahue, Ruppert, Bauer, Ashkenazi: Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. in Current biology : CB 1997
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Human Monoclonal TNFSF10 Primary Antibody for BCA, BR - ABIN1176947
Kayagaki, Yamaguchi, Nakayama, Kawasaki, Akiba, Okumura, Yagita: Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN2689130
Mariani, Matiba, Armandola, Krammer: Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells. in The Journal of cell biology 1997
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Human Monoclonal TNFSF10 Primary Antibody for WB - ABIN1169389
Huber, Fais, Iero, Lugini, Canese, Squarcina, Zaccheddu, Colone, Arancia, Gentile, Seregni, Valenti, Ballabio, Belli, Leo, Parmiani, Rivoltini: Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. in Gastroenterology 2005
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Mouse (Murine) Monoclonal TNFSF10 Primary Antibody for FACS, WB - ABIN2689128
Mariani, Krammer: Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells. in European journal of immunology 1998
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Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN4897836
Kalb, Glaser, Stary, Koszik, Stingl: TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Monoclonal TNFSF10 Primary Antibody for FACS - ABIN1383744
Herbeuval, Boasso, Grivel, Hardy, Anderson, Dolan, Chougnet, Lifson, Shearer: TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells. in Blood 2005
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Human Monoclonal TNFSF10 Primary Antibody for Func, FACS - ABIN1690743
Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed: Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. in Cancer research 2005
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Human Polyclonal TNFSF10 Primary Antibody for IF (p), IHC (p) - ABIN673494
Fang, Zhang, Qi, Fan, Luo, Liu, Tan: Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells. in PLoS ONE 2014
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It is a apoptosis related protein.
investigation of the gene polymorphisms in TRAIL molecular pathway and TRAIL gene expression levels in non-small cell lung cancer (NSCLC) patients in terms of pathogenesis and prognosis of the disease
TRAIL polymorphisms were significantly associated with susceptibility to intervertebral disc degeneration in Chinese Han population.
Findings show that a combination of CRP, PCT, TRAIL and IP-10 can identify bacterial infections with higher accuracy than single biomarkers and combinations of a single bacterial biomarkers combined with TRAIL and IP-10.
HBx synergizes with proinflammatory cytokines to significantly increase TRAIL-induced apoptosis of renal tubular epithelial cells.
AXIN1 and TRAIL were shown to be able to discriminate between traumatic brain injury (TBI) severity within the first hour highlighting them as new TBI biomarkers.
The objective of this study was to evaluate the expression profile of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with diabetic nephropathy.
Our results indicate that vitamin D status in mothers modulates TRAIL expression in breast milk, which may have implications for both mother and infant health.
The C allele at the rs631090 locus of C1q, the G allele at 1525A/G site of TRAIL, and the G allele of Tim-1 at -1454G/A site are susceptibility variants associated with SLE. The frequency of the G allele at the 1525A/G locus of TRAIL gene in the study group was significantly higher than those in the control group.
TRAIL protects against insulin resistance, NAFLD and vascular inflammation. Increasing TRAIL levels may be an attractive therapeutic strategy, to reduce features of diabetes, as well as liver and vascular injury, so commonly observed in individuals with NAFLD.
data strongly suggest that XIAP-mediated inhibition of final caspase-3 processing is the last and major hurdle in TRAIL-induced apoptosis in NCI-H460 cells, which can be overcome by Smac in a Bcl-2 level dependent manner.
Patients harboring the homozygous AA genotype of TRAIL SNPs rs1131568 and rs1131579 and the TT genotype of the TRAIL SNP rs1131580 had lower overall survival and higher rates of extrahepatic recurrence (EHR) than patients harboring the wild type or heterozygous genotypes.
TRAIL synergistically sensitized irradiation-induced apoptosis in glioblastoma stem-like cells by increasing DR5 expression and decreasing cFLIP expression.
Serum TRAIL concentrations are significantly reduced in patients with early preeclampsia.
The combination treatment with ILz:rhTRAIL and bortezomib was able to induce cell death in both TRAIL-susceptible and TRAIL-resistant cancer cells through the intracellular TRAIL signaling pathway. The efficiency of cell death was dependent on the properties of TRAIL under the environment provided by bortezomib. The combination treatment-induced cell death was not regulated by bortezomib-induced ER stress response or by a
A significant relationship was found between TRAIL polymorphisms and the susceptibility and severity of intervertebral disc degeneration in Han Chinese.
The authors demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism.
High expression level of Galectin-3 and low expression level of TRAIL were found to be positively correlated with the shorter median survival time and overall survival time.
Genes related to the extrinsic pathway of apoptosis including a receptor for TRAIL.
Nelfinavir induces ER stress in renal cancer cells and sensitizes them to TRAIL.
TRAIL/TRAIL-R interaction regulates CD4(+) T cell activation in autoimmune inflammation and directly suppresses T cell activation via inhibiting TCR signaling, suggesting that TRAIL-R serves as a novel immune checkpoint in T cell responses.
Isolated highly-pure population of DcR2-positive renal tubular epithelial cells was isolated by MACS, which was confirmed to comprise of active senescent RTECs based on the cell cycle phase.
In this study, the authors identified by gene expression profiling that microgravity induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL stimulation compared to ground based cultures.
Data suggest that the CXCL9-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
this study shows pathogenic role for TRAIL in chronic obstructive pulmonary disease
downregulation of cIAPs in PSC cholangiocytes may contribute to the development of the disease. Our results also indicate that inhibition of TRAIL signaling pathways may be beneficial in the treatment of PSC
pCLE results indicated that endomicroscopy could effectively quantify injected MSCs that homed to subcutaneous xenograft tumor sites in vivo and correlated well with the therapeutic effects of the TRAIL gene
the aim of this study is to elucidate the role of TRAIL during rhinovirus (RV) infection in vivo.
Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.
Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio.
Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.(
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4/eNOS/nitric oxide signaling.
Study reports that loss of the Opg gene results in deterioration of abdominal aortic aneurysms (AAA), possibly through involvement of TRAIL in smooth muscle actin (SMA)-positive cells and myofibroblasts.
PARP1 acts as a prominent upstream regulator of high mobility group box 1-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Data suggest that Socs3 (suppressor of cytokine signaling 3) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase/AP-1 transcription factor signaling.
These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70.
These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald burns
TRAIL-deficiency in ApoE(-/-) mice exacerbates nephropathy and insulin resistance
TRAIL induces apoptosis in tissue-infiltrating neutrophils thereby protecting organs from sepsis-induced injury.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.
The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.
xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs, presumably owing to PKC activation, as part of the mechanism for RBC switching
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, TNF-related apoptosis inducing ligand TRAIL
, chemokine tumor necrosis factor ligand superfamily member 10
, tumor necrosis factor (ligand) family, member 10
, tumor necrosis factor apoptosis-inducing ligand splice variant delta
, tumor necrosis factor ligand superfamily member 10
, TNF-related apoptosis inducing ligand
, TNF-related apoptosis-inducing ligand
, tumor necrosis factor-related apoptosis-inducing ligand
, TNF-related apoptosis-inducing ligand 1
, tumor necrosis factor related apoptosis inducing ligand 1
, tumor necrosis factor (ligand) superfamily, member 10 like 2
, tumor necrosis factor (ligand) superfamily, member 10
, tumor necrosis factor ligand 6A
, tumor necrosis factor superfamily member 10