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Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

1. A significant relationship was found between TRAIL polymorphisms and the susceptibility and severity of intervertebral disc degeneration in Han Chinese.

2. The authors demonstrate that BAP1 (show RNF2 Proteins) deubiquitinase activity and its association with ASXL1 (show ASXL1 Proteins) to form the Polycomb (show CBX2 Proteins) repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism.

3. High expression level of Galectin-3 (show LGALS3 Proteins) and low expression level of TRAIL were found to be positively correlated with the shorter median survival time and overall survival time.

4. DR5 (show TNFRSF10B Proteins)-Cbl-b/c-Cbl (show CBL Proteins)-TRAF2 (show TRAF2 Proteins) complex inhibited TRAIL-induced apoptosis by promoting TRAF2 (show TRAF2 Proteins)-mediated polyubiquitination of caspase-8 (show CASP8 Proteins) in gastric cancer cells.

5. We found that the combination of alpha-mangostin with TRAIL induced apoptosis of SAS (show TSPAN31 Proteins) cells through the mitochondrial pathway via activation of caspase-9 (show CASP9 Proteins) and -3/7, following release of cytochrome c (show CYCS Proteins). This apoptosis was induced by S/G2 (show STRN3 Proteins)/M-phase arrest. Immunopositivity for c-Myc (show MYC Proteins) was observed in the cytoplasm of tumor cells in 16 (40%) of the 40 cases of human oral squamous cell carcinoma (HOSCC).

6. this study characterized in juvenile systemic lupus erythematosus a distinct profile from adult SLE that comprises increased sFas, sTRAIL, and reduced sFasL (show FASL Proteins), notably in patients with active disease and with nephritis.

7. Notch1 (show NOTCH1 Proteins) activation also suppressed A549 cell apoptosis by inhibiting the PI3K (show PIK3CA Proteins)/pAkt (show AKT1 Proteins) pathway and activating the caspase-3 (show CASP3 Proteins) pathway in cooperation with TRAIL. Combining Notch1 (show NOTCH1 Proteins) signal with TRAIL inhibited PI3K (show PIK3CA Proteins), phosphorylated Akt (show AKT1 Proteins) and phosphorylated STAT3 (show STAT3 Proteins) expressions.

8. we show that executioner caspase (show CASP3 Proteins) activation of the apoptotic nuclease (show DCLRE1C Proteins) CAD/DFF40 (show DFFB Proteins) is essential for TRAIL-induced mutations in surviving cells. As exposure to chemotherapy drugs also activates apoptotic caspases and presumably CAD, we hypothesized that these pathways may also contribute to the mutagenesis induced by conventional chemotherapy drugs, perhaps augmenting the mutations that arise from direct DNA damage

9. Cultured HCN-2 (show HCN2 Proteins) neurons were incubated at different times with GITRL (show TNFSF18 Proteins) and/or TRAIL, and thereafter nucleic acid and protein expression were measured. HCN-2 (show HCN2 Proteins) cells do not express GITRL (show TNFSF18 Proteins) mRNA, but the latter is induced after treatment with TRAIL. Cells did not express the GITRL (show TNFSF18 Proteins) receptor GITR (show TNFRSF18 Proteins) mRNA, neither in control cultures, nor after treatment with TRAIL. TRAIL, when associated to GITRL (show TNFSF18 Proteins), exerted additive toxic effects.

10. OPG (show TNFRSF11B Proteins) and OPG (show TNFRSF11B Proteins)/TRAIL ratio expression were significantly increased in rheumatoid arthritis patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG (show TNFSF11 Proteins) ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL (show TNFSF11 Proteins) and TRAIL expression.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

1. Isolated highly-pure population of DcR2 (show TNFRSF10D Proteins)-positive renal tubular epithelial cells was isolated by MACS, which was confirmed to comprise of active senescent RTECs based on the cell cycle phase.

2. In this study, the authors identified by gene expression profiling that microgravity induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL (show TNFSF11 Proteins) stimulation compared to ground based cultures.

3. Data suggest that the CXCL9 (show CXCL9 Proteins)-CXCR3 (show CXCR3 Proteins) axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.

4. Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.

5. Diabetes significantly increased OPG (show TNFSF11 Proteins) and the OPG (show TNFSF11 Proteins)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (show TNFSF11 Proteins) and reduced TRAIL expression, thus increasing cardiac OPG (show TNFSF11 Proteins)/TRAIL ratio.

6. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (show NOX4 Proteins)/eNOS (show NOS3 Proteins)/nitric oxide signaling.

7. Study reports that loss of the Opg (show TNFSF11 Proteins) gene results in deterioration of abdominal aortic aneurysms (AAA (show AAAS Proteins)), possibly through involvement of TRAIL in smooth muscle actin (SMA (show SMN1 Proteins))-positive cells and myofibroblasts.

8. PARP1 (show PARP1 Proteins) acts as a prominent upstream regulator of high mobility group box 1 (show HMGB1 Proteins)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance

9. Data suggest that Socs3 (suppressor of cytokine signaling 3 (show SOCS3 Proteins)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (show MAPK8 Proteins)/AP-1 (show JUN Proteins) transcription factor signaling.

10. These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (show HSP70 Proteins).

Pig (Porcine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

1. Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.

2. The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.

Xenopus laevis Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) interaction partners

1. xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (show SSU1 Proteins), presumably owing to PKC activation, as part of the mechanism for RBC (show CACNA1C Proteins) switching