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In the present study, we analyze the 14-3-3/SOS1 protein-protein interaction (PPI) by different biochemical assays and report the high resolution crystal structure of a 13-mer motif of SOS1 bound to 14-3-3 zeta
14-3-3 zeta is significantly expressed in glioblastoma multiforme (grade IV) and 14-3-3 zeta expression levels enhanced according to the increase of astrocytoma malignancy. Apoptosis properties, including DNA fragmentation and ratio increase of Bax/Bcl-2 are observed in astrocytes following reduction of 14-3-3 zeta protein expression. Mitochondrial pathway is involved in the apoptosis induction.
Circ-SERPINE2 repressed solid tumour growth through enhancing miR-375 expression and reducing YWHAZ expression in vivo.
14-3-3zeta is up-regulated in and inhibited the anti-tumor functions of tumor-infiltrating T cells in hepatocellular carcinoma microenvironment.
YWHAZ silencing resulted in cell cycle arrest in gastric cancer BGC-823 cells.
14-3-3zeta promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-kappaB signaling
The results suggest that YWHAZ is the most suitable as the reference gene in human mononuclear leukocytes.
YWHAZ is upregulated in ovarian cancers in contrast to normal tissues. High YWHAZ expression was found to be associated with TNM stage and metastasisfree prognosis of ovarian cancer patients.
Amount of 14-3-3 proteins is decreased in pineal gland, blood platelets and ileum of patients with ASD.
These results imply that disorder in the N-terminal helices of 14-3-3 zeta is a consequence of the dimer-monomer dynamics and may play a role in conferring chaperone function to 14-3-3 zeta protein.
Knockdown of YWHAZ inhibited cell cycle progression, migration, and the expression of stem cell markers and tumorigenicity was suppressed in tumor-bearing BALB/c nude mice. The expression of YWHAZ was directly down-regulated by miR-30e in resistant ovarian cancer cells.
our data suggest miR-204 and 14-3-3zeta as potential therapeutic targets in osteosarcoma
evidence is lacking to conclude that 14-3-3zeta is a useful marker of tamoxifen resistance.
TRIM21 positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 and its expression levels were negatively regulated by TRIM21.
several disordered regions of PI4KB become protected from proteolytical degradation upon 14-3-3 binding.
Ectopic expression of miR-451 could inhibit the cell migration and invasion, promoted apoptosis, induced cell-cycle arrest Furthermore, tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein zeta (YWHAZ) was identified as a direct target of miR-451
Serum autoantibodies to YWHAZ are produced at substantially greater levels in gastric cancer patients as compared to controls.
Dimerization of 14-3-3 zeta (14-3-3zeta) dimer was disrupted by a double mutant (L12E, M78K).
Results identified YWHAZ as the direct target of miR-613 in hepatocellular carcinoma (HCC). Its overexpression reverses the tumor suppressing role of miR-613 in HCC cells.
14-3-3zetaoverexpression might be a potential prognostic biomarker for ovarian cancer.
The expression of zeta isoforms of 14-3-3 protein was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
Collectively, these results demonstrate that14-3-3/14-3-3varsigma participates in the regulation of retinal axon elongation, in part by modulating XAC activity.
Caspase-2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool
It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain.
DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR-146a may be a potential target for asthma therapy.
When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1-dependent mechanisms.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.
Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
PKCdelta-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1, even when FOXO1 is phosphorylated as under non-stress conditions
analysis of phosphorylation-dependent interactions of AQP2 with 14-3-3theta; and -zeta
14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder.
Ywhaz coordinates adipogenesis in visceral fat.
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
In the majority of NAFLD treatment groups and time points the most stable gene was YWHAZ.
By preventing the inactivation of cofilin, metabolic stress-induced degradation of 14-3-3zeta promotes the conversion of blood monocytes into a hypermigratory, proatherogenic phenotype.
14-3-3zeta KO mice displayed enhanced locomotor hyperactivity induced by the dopamine (DA) releaser amphetamine. Consistent with 14-3-3zeta having a role in DA signalling, we found increased levels of DA in the striatum of 14-3-3zeta KO mice.
The activated serine/threonine kinase Akt/protein kinase B phosphorylated BTK on two sites prior to 14-3-3 zeta binding.
studies demonstrate that increased 14-3-3zeta levels protect against ER stress and seizure-damage despite down-regulation of the unfolded protein response
Increased degradation of 14-3-3zeta in lysosomes in the absence of TTR, increasing autophagy.
Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways.
Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell.
14-3-3 zeta as the only prognosticator of local recurrence-free survival (LRFS) and also an independently predicted factor of disease-specific survival (DSS).
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in YWHAZ.
Our collective data demonstrate the complexity of 14-3-3/Tau interactions in vivo and suggest that 14-3-3 attenuation is not appropriate ameliorative treatment of Tauopathies. Finally, we suggest that 'bystander' 14-3-3s are recruited by accumulating Tau with the consequences depending on the composition of available dimers within particular neurons and the Tau variant.
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb.
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Hpo signaling inhibited Yki nuclear localization and activity by phosphorylating Yki and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki activity through modulating its subcellular localization.
in vivo 14-3-3zeta monomer properties and functionality
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
These observations provide the first direct evidence that a 14-3-3 protein functions as a stress-induced molecular chaperone that dissolves and renaturalizes thermal-aggregated proteins.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
, 14-3-3 protein zeta/delta
, 14-3-3 protein/cytosolic phospholipase A2
, 14-3-3 zeta
, phospholipase A2
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
, 14-3-3 protein zeta
, tyrosine 3-monooxygenase protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b
, factor activating exoenzyme S
, mitochondrial import stimulation factor S1 subunit
, 14-3-3 protein zeta a
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide a
, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide
, D14 3 3 protein
, complementation group K
, leonardo 14-3-3
, tyrosine 3-monooxygenase
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide