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Epidermal Cell Markers

Epidermal cells form the epidermis. It is the outermost of the three layers that together form the skin. Epidermis consists of four squamous epithelial layers, which are arranged vertically. From outside to inside these are: Cornified layer (stratum corneum), granular layer (stratum granulosum), spinous layer (stratum spinosum), basal cell layer (stratum basale).

antibodies-online offers an excellent selection of antibodies, kits and tools for the investigation of epidermal cells. Below you will find hand-picked, reliable products for some of the important targets.

Cornified Layer (stratum corneum)

The stratum corneum (SC), the horny layer of the mammalian epidermis, directly faces the external environment and protects the inner viable layers from desiccation and foreign insult. The SC consists of layers of cornified keratinocytes (corneocytes) attached to each other by corneodesmosomes, with intercellular spaces sealed with lipids. The intracellular space of corneocytes is filled with keratin filaments, filaggrin, and their degradation products. Important targets are Loricrin, Involucrin, S100 proteins, Periplakin, Envoplakin.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Application WB, IHC (p)
Cat. No. ABIN5647242
Quantity 100 μg
Reactivity Human
Clonality Monoclonal
Application WB, ELISA, IHC
Cat. No. ABIN1724663
Quantity 100 μL

Granular Layer (stratum granulosum)

3-5 cell layers, contains diamond shaped cells with keratohyalin granules and lamellar granules. Keratohyalin granules contain keratin precursors that eventually aggregate, crosslink, and form bundles. The lamellar granules contain the glycolipids that get secreted to the surface of the cells and function as a glue, keeping the cells stuck together. Important targets are Cytokeratin 1, Cytokeratin 2, Cytokeratin 10, Filaggrin, Transglutaminase 3.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
Reactivity Dog, Human, Mouse, Rat, Zebrafish (Danio rerio)
Clonality Monoclonal
Application WB, FACS, IHC, ICC, IHC (fro)
Cat. No. ABIN335328
Quantity 0.1 mg
Reactivity Human
Clonality Monoclonal
Application IF, FACS, IHC (p)
Cat. No. ABIN5578197
Quantity 100 μg
Reactivity Human
Clonality Polyclonal
Application IHC, ELISA, IHC (fro)
Cat. No. ABIN110114
Quantity 100 μL

Spinous Layer (stratum spinosum)

Above the basal cell layer rest polyhedral cells which occupy larger volume and this layer is called the stratum spinosum. The tonofilaments become denser in the spinous layer than the basal cell layer. The tonofilaments turn and loop into the attachment plaque (intracellular portion of the desmosomes). The protein-synthesizing activity of the spinous cell layer is more, indicating its biochemical changes and commitment to keratinization. Important targets are Transglutaminase 1, Transglutaminase 5.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
Reactivity Human
Clonality Polyclonal
Application WB, IHC
Cat. No. ABIN6149097
Quantity 100 μL
Reactivity Human
Clonality Polyclonal
Application WB, IP
Cat. No. ABIN950045
Quantity 100 μL

Basal Cell Layer (stratum basale)

The inner layer, called the basal layer (or stratum germinativum), is a germinal epithelium that gives rise to all the cells of the epidermis. The basal layer divides to give rise to another, outer population of cells that constitutes the spinous layer. Important targets are Cytokeratin 5, Cytokeratin 14, Cytokeratin 15.

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
Reactivity Dog, Human, Pig, Rat
Clonality Monoclonal
Application WB, IHC, FACS, ICC, IHC (fro)
Cat. No. ABIN335329
Quantity 0.1 mg

Important Targets related to Epidermal Cells

The following targets are directly related to research on Epidermal Cells. Search Antibodies, Kits, Reagents and other products.

References

Kubo, Ishizaki, Kubo, Kawasaki, Nagao, Ohashi, Amagai: "The stratum corneum comprises three layers with distinct metal-ion barrier properties." in: Scientific reports, Vol. 3, pp. 1731, (2014) (PubMed).

Deo, Deshmukh: "Pathophysiology of keratinization." in: Journal of oral and maxillofacial pathology : JOMFP, Vol. 22, Issue 1, pp. 86-91 (PubMed).

  • Hani Yousef; Mandy Alhajj; Sandeep Sharma. Anatomy, Skin (Integument), Epidermis. Last Update: June 12, 2019. www.ncbi.nlm.nih.gov/books/NBK470464/
  • Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA), 2000.
Rene von der Forst
Rene von der Forst, MSE
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Master of Science in engineering. 12+ years of experience in marketing and e-commerce in the life science sector.

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