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Human MAP1LC3B Protein expressed in Wheat germ - ABIN1310156
Martinet, Schrijvers, Timmermans, Bult, De Meyer: Immunohistochemical analysis of macroautophagy: recommendations and limitations. in Autophagy 2013
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presence of LC3B puncta and HMGB1 (show HMGB1 Proteins) expression in malignant cells correlate with the immune infiltrate in breast cancer
the L341V mutation limits the critical step of SQSTM1 (show SQSTM1 Proteins) recruitment to the phagophore
LC3B and p62 have roles in autophagy in esophageal adenocarcinoma
Data indicate that tubule-associated protein 1 light chain 3 beta (LC3B) can be potentially useful for identifying autophagosomes and differentiating their developmental stages.
analysis of the RavZ and LC3 (show MAP1LC3A Proteins) complex reveals the mechanism for deconjugation of LC3 (show MAP1LC3A Proteins) on the phagophore membrane
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Cardiolipin interaction with various Atg8 (show GABARAPL2 Proteins) human orthologs, namely LC3B, GABARAPL2 (show GABARAPL2 Proteins) and GABARAP (show GABARAP Proteins), was investigated.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
Determined is the three-dimensional crystal structures of LC3B in complex with three different LIR (show CD300C Proteins) motifs of RavZ from Legionella pneumophila, an intracellular pathogen that can manipulate the host autophagy system.
We found that 25-epi (show TFPI Proteins) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Proteins) expression, increased expression of the ER stress marker CHOP (show DDIT3 Proteins), loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B.
Data show that interaction between miR (show MLXIP Proteins)-471-5p and autophagy member proteins regulates clearance of apoptotic germ cells via LC3 (show MAP1LC3A Proteins)-associated phagocytosis (LAP).
The crystal structure of mouse LC3B in complex with the FYCO1 (show FYCO1 Proteins) LC3 (show MAP1LC3A Proteins)-interacting region (LIR (show CD300C Proteins)) reveals the importance of the flanking region of the LIR (show CD300C Proteins) motif.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 (show SQSTM1 Proteins) and Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Proteins) and down-regulates Lc3 (show MAP1LC3A Proteins)-II in neonatal liver. (p62/Sqstm1 (show SQSTM1 Proteins) = sequestosome 1 (show SQSTM1 Proteins); Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 = microtubule-associated protein (show SPAG5 Proteins) 1-light chain 3)
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2 (show TRDMT1 Proteins)) siRNA restored the expression of Atg5 (show ATG5 Proteins) and LC3 (show MAP1LC3A Proteins) in vivo and in vitro.
MREG (show MREG Proteins)-dependent processing links both autophagic and phagocytic processes in LC3 (show MAP1LC3A Proteins)-associated phagocytosis. MREG (show MREG Proteins) participates in coordinating the association of phagosomes with LC3 (show MAP1LC3A Proteins) for content degradation with the MREG (show MREG Proteins) loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1 (show MOAP1 Proteins)-LC3b mediates IL-17 (show IL17A Proteins)-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1 (show IL1A Proteins).
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3 (show MAP1LC3A Proteins)-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3 (show MAP1LC3A Proteins)/GABARAP (show GABARAP Proteins) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (show ATG3 Proteins).
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR (show FRAP1 Proteins), Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, microtubule-associated proteins 1A/1B light chain 3B
, MAP1A/1B light chain 3 B
, autophagy-related protein LC3 B
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated protein 1 light chain 3 beta