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Human MAP1LC3B Protein expressed in Wheat germ - ABIN1310156
Martinet, Schrijvers, Timmermans, Bult, De Meyer: Immunohistochemical analysis of macroautophagy: recommendations and limitations. in Autophagy 2013
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LC3 may influence the perineural invasion and prognosis of pancreatic cancer through ubiquitin C
Two isoforms of ATG7 are expressed in various tissues. ATG7(2) does not bind LC3B. ATG7(2) is unable to lipidate LC3/GABARAP.
HIF-1alpha reduced recruitment of Histoplasma capsulatum -induced LC3-II to the phagosome.
Study found that TBC1D9B, a GTPase activating protein for RAB11A, interacted with LC3B. TBC1D9B could also interact with other mammalian ATG8 homologues and revealed that TBC1D9B can positively regulate autophagic flux, possibly through its GTPase activity to inactivate RAB11A, facilitating the proper destination of the autophagosomes to the degradation.
These results suggested that the DNA sequence variants identified in acute myocardial infarction patients may change LC3B level by affecting the transcriptional activity of LC3B gene promoter, contributing to the acute myocardial infarction development. Upregulation of the LC3B gene expression may provide a novel and potential therapy for acute myocardial infarction patients.
HSP27 expression at diagnosis or after neoadjuvant chemotherapy is a negative prognostic marker in osteosarcoma. Patients whose tumors lack LC3B+ puncta and express HSP27 following neoadjuvant chemotherapy have a particularly high risk for disease relapse and death. These findings establish HSP27 and LC3B+ puncta as prognostic biomarkers in osteosarcoma
Trim5alpha binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a beta-strand motif comprising approximately six residues, LC3B binds to Trim5alpha via the alpha-helical coiled-coil region.
The Calcium sensing receptor (CaSR) promotes degradation of key regulators of NLRP3 inflammasome and studied the role of Hsp70 chaperone and LC3-II to activate the NLRP3 inflammasome and produce mature IL-1b.
Results indicate the basal level of autophagy and microtubule associated protein 1 light chain 3 beta (MAP1LC3B-II) protein as potential biomarkers for docosahexaenoic acid (DHA) sensitivity in colorectal cancer (CRC) cells.
After blocking the beta-glucan receptor (CR3) or inhibiting downstream kinase (SYK) in neutrophils, the killing percent to C. albicans (regardless of endemic and non-endemic strains) and the ratio of LC3B-II/I of neutrophils were significantly decreased.
Data show that autophagy related 16 like 1 (ATG16L1) isoforms mechanistically distinguish between different microtubule associated protein 1 light chain 3 beta (LC3B) lipidation mechanisms under different cellular conditions.
using dominant negative forms of ATG proteins, we demonstrate that ATG5-12 conjugate, but not LC3-II formation, is critical for viral replication. Altogether, these findings suggest that although HCV needs the elongation complex for its replication, it has developed a mechanism to avoid canonical LC3-II accumulation at viral replication site.
High LC3B expression correlates with poor prognosis in oropharyngeal and oral cavity squamous cell carcinoma
Cav3.1 and LC3-II proteins are highly expressed in BRAFV600E compared with NRAS mutant melanomas, both in cell lines and biopsies.
Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and 3B (LC3A, LC3B) and beclin-1.
Novel genetic associations was found between LC3B (encoded by MAP1LC3B), an excellent marker for autophagic structures, and susceptibility to systemic lupus erythematosus.
Study demonstrated that the expression of LC3B was upregulated in 4nitroquinoline1oxideinduced oral carcinogenesis, accompanied with myeloidderived suppressor cells and regulatory T cells accumulation.
High p62 cytoplasmic expression on its own (p = 0.001), or in combination with low LC3B (p = 0.034), was associated with nonresponse to chemotherapy, regardless of whether or not the regiments contained paclitaxel, but there was no independent prognostic value of LC3B or p62 expression patterns for esophageal adenocarcinomas .
Here the authors present evidence for phosphorylation-driven regulation of the Nix:LC3B interaction. Isothermal titration calorimetry and NMR indicate a ~100 fold enhanced affinity of the serine 34/35-phosphorylated Nix LC3-interacting region (LIR) to LC3B and formation of a very rigid complex compared to the non-phosphorylated sequence.
The results suggest that autophagy-associated proteins LC3A, LC3B, and Beclin-1 might be potential biomarkers for subclassification, differentiation, and local metastasis in primary lung tumor.
In mouse RPE and neural retina, LC3A and LC3B were expressed at approximately equivalent levels. LC3B protein was detected in C57Bl6/J RPE and retinal lysates and was absent in the LC3BKO mouse.
At the microtubule-actin crossover junction, ATG4B detaches LC3B from melanosomal membranes by enzymatic delipidation.
Data show that interaction between miR-471-5p and autophagy member proteins regulates clearance of apoptotic germ cells via LC3-associated phagocytosis (LAP).
The crystal structure of mouse LC3B in complex with the FYCO1 LC3-interacting region (LIR) reveals the importance of the flanking region of the LIR motif.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3-II/Map1lc3 in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 and down-regulates Lc3-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3-II/Map1lc3 = microtubule-associated protein 1-light chain 3)
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro.
MREG-dependent processing links both autophagic and phagocytic processes in LC3-associated phagocytosis. MREG participates in coordinating the association of phagosomes with LC3 for content degradation with the MREG loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
p62/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia.
Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice.
LC3B plays a regulatory role in hyperoxia-induced epithelial apoptosis
The model and biochemical data provide a rationale for Atg7 dimerization: Atg8 is transferred in trans from the catalytic cysteine of one Atg7 protomer to Atg3 bound to the N-terminal domain of the opposite Atg7 protomer within the homodimer.
The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of pulmonary hypertension
a mechanism by which LC3B, through interactions with Cav-1 and Fas, can regulate apoptosis.
MAP1B is involved in the initial stages of axonogenesis, as shown by reduced axon length and increased growth cone size of cultured dorsal root ganglion neurons from MAP1B deficient mice.
Results suggest novel compensatory mechanisms for loss of LC3beta, ensuring proper FN accumulation and autophagy during fetal and neonatal life.
Data indicate that the expression of MAP1LC3A, B and autophagy-associated genes (ATG5, mTOR, Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, microtubule-associated proteins 1A/1B light chain 3B
, MAP1A/1B light chain 3 B
, autophagy-related protein LC3 B
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated protein 1 light chain 3 beta