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anti-Human PLAT Antibodies:
anti-Mouse (Murine) PLAT Antibodies:
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Mouse (Murine) Polyclonal PLAT Primary Antibody for ELISA (Detection), IHC (fro) - ABIN491324
Bi Oh, Suh, Kim, Lee: Impacts of aging and amyloid-? deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease. in Brain research 2015
Show all 4 Pubmed References
Mouse (Murine) Polyclonal PLAT Primary Antibody for ELISA (Detection), WB - ABIN491292
Bavelloni, Piazzi, Raffini, Faenza, Blalock: Prohibitin 2: At a communications crossroads. in IUBMB life 2015
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Human Polyclonal PLAT Primary Antibody for ELISA (Detection), IHC (fro) - ABIN491321
Pawlak, Melchor, Matys, Skrzypiec, Strickland: Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Mouse (Murine) Polyclonal PLAT Primary Antibody for AC, ELISA (Capture) - ABIN491261
Fredriksson, Stevenson, Su, Ragsdale, Moore, Craciun, Schielke, Murphy, Lawrence: Identification of a neurovascular signaling pathway regulating seizures in mice. in Annals of clinical and translational neurology 2015
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Mouse (Murine) Polyclonal PLAT Primary Antibody for ELISA (Detection), WB - ABIN490939
Dahlem, Bos, Haitsma, Schultz, Wolthuis, Meijers, Lachmann: Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury. in The European respiratory journal 2006
Show all 2 Pubmed References
Mouse (Murine) Polyclonal PLAT Primary Antibody for AC, ELISA (Detection) - ABIN491312
Wu, Torre, Cuellar-Giraldo, Cheng, Yi, Bichler, García, Yepes: Tissue-type plasminogen activator triggers the synaptic vesicle cycle in cerebral cortical neurons. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
Show all 2 Pubmed References
Human Polyclonal PLAT Primary Antibody for EIA, IHC (fro) - ABIN191536
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
Human Polyclonal PLAT Primary Antibody for IF (p), IHC (p) - ABIN731123
Balaoing, Post, Liu, Minn, Grande-Allen: Age-related changes in aortic valve hemostatic protein regulation. in Arteriosclerosis, thrombosis, and vascular biology 2013
Mouse (Murine) Polyclonal PLAT Primary Antibody for ELISA (Detection), IHC (fro) - ABIN491323
Giacobini, Messina, Wray, Giampietro, Crepaldi, Carmeliet, Fasolo: Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
PAI-1 (show SERPINE1 Antibodies)/tPA ratio may be an important parameter to monitor the progression of OSMF, and normalizing this ratio to 1:1 may reinstate the normal healing pattern in OSMF cases
The concentration of tPA/PAI-1 (show SERPINE1 Antibodies) complex is an independent predictor of mortality from all causes and from cardiovascular causes in patients with heart failure and preserved ejection fraction.
Underexpression of Tissue plasminogen activator is associated with diabetic foot syndrome.
By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.
tPA is a ligand of the N-terminal domain of the obligatory GluN1 (show GRIN1 Antibodies) subunit of NMDAR (show GRIN1 Antibodies) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.
t-PA binds to Lys91 in the MBP (show MBL2 Antibodies) NH2-terminal region and PLGbinds to Lys122 in the MBP (show MBL2 Antibodies) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.
local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (show PLG Antibodies) system toward the end of gestation. This may contribute to the ROM (show ROM1 Antibodies) at both term and preterm birth.
We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.
Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP (show LRP1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/Cox-2 (show COX2 Antibodies) in endothelial cells, endothelial MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies) activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion.
Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons.
analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations
A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).
While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.
mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA
administration of ADAMTS13 (show ADAMTS13 Antibodies) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Antibodies) patency and consequently reduced cerebral infarct sizes
strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Antibodies)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.
The plasminogen/plasminogen (show PLG Antibodies) activator/plasmin (show PLG Antibodies) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Antibodies) production, consistent with a role in extracellular matrix remodeling during follicle growth
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Antibodies) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.
Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.
a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile
ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
, plasminogen activator, tissue type
, t-plasminogen activator
, tissue plasminogen activator (t-PA)
, tissue-type plasminogen activator
, tissue plasminogen activator
, T-plasminogen activator
, plasminogen activator, tissue
, tissue-type plasminogen activator-like