PLAT antibody (AA 371-399)

Catalog No. ABIN3032243

The Rabbit Polyclonal anti-PLAT antibody is suitable to detect PLAT in samples from Human. It has been validated for WB, IHC, ELISA and FACS.

Quick Overview for PLAT antibody (AA 371-399) (ABIN3032243)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Product Details anti-PLAT Antibody

Binding Specificity: AA 371-399

Purpose: tPA Antibody / Tissue Plasminogen Activator

Purification: Purified

Immunogen: A portion of amino acids 371-399 from the human protein was used as the immunogen for this tPA antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the tPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the tPA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA

Background: TPA is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome