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Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491602
Chen, Chu, Brumberg: Experience-dependent regulation of tissue-type plasminogen activator in the mouse barrel cortex. in Neuroscience letters 2015
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Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491605
Lin, Jin, Mars, Reeves, Hu: Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. in The American journal of pathology 2014
Show all 9 Pubmed References
Human PLAT Protein expressed in CHO Cells - ABIN491596
Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. in European journal of trauma and emergency surgery : official publication of the European Trauma Society 2015
Show all 5 Pubmed References
Human PLAT Protein expressed in Insect Cells - ABIN491597
Lin, Jin, Hu: Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. in The Journal of biological chemistry 2015
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Human PLAT Protein expressed in CHO Cells - ABIN491600
Shahrour, Keck, Jankun: Application of long-acting VLHL PAI-1 during sutureless partial nephrectomy in mice reduces bleeding. in BioMed research international 2015
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Human PLAT Protein expressed in Insect Cells - ABIN491598
Mantuano, Lam, Shibayama, Campana, Gonias: The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. in Journal of cell science 2015
Show all 2 Pubmed References
Rat (Rattus) PLAT Protein expressed in Insect Cells - ABIN491404
Yeh, Huang, Hsu: Prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF. in The Journal of physiology 2012
Show all 2 Pubmed References
Human PLAT Protein expressed in CHO Cells - ABIN491026
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Pig (Porcine) PLAT Protein expressed in Insect Cells - ABIN491402
Bongoni, Kiermeir, Schnider, Jenni, Garimella, Bähr, Klymiuk, Wolf, Ayares, Voegelin, Constantinescu, Seebach, Rieben: Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions. in Transplantation 2015
PAI-1 (show SERPINE1 Proteins)/tPA ratio may be an important parameter to monitor the progression of OSMF, and normalizing this ratio to 1:1 may reinstate the normal healing pattern in OSMF cases
The concentration of tPA/PAI-1 (show SERPINE1 Proteins) complex is an independent predictor of mortality from all causes and from cardiovascular causes in patients with heart failure and preserved ejection fraction.
Underexpression of Tissue plasminogen activator is associated with diabetic foot syndrome.
By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen (show PLG Proteins) to efficiently generate plasmin (show PLG Proteins); this aggregate-bound plasmin (show PLG Proteins) is shielded from inhibition by alpha-2-antiplasmin (show Alpha2 Antiplasmin Proteins) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.
tPA is a ligand of the N-terminal domain of the obligatory GluN1 (show GRIN1 Proteins) subunit of NMDAR (show GRIN1 Proteins) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.
t-PA binds to Lys91 in the MBP (show MBL2 Proteins) NH2-terminal region and PLGbinds to Lys122 in the MBP (show MBL2 Proteins) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.
local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (show PLG Proteins) system toward the end of gestation. This may contribute to the ROM (show ROM1 Proteins) at both term and preterm birth.
We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.
Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP (show LRP1 Proteins)/NF-kappaB (show NFKB1 Proteins)/Cox-2 in endothelial cells, endothelial MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion.
Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons.
analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations
A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).
While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.
mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA
administration of ADAMTS13 (show ADAMTS13 Proteins) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Proteins) patency and consequently reduced cerebral infarct sizes
strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Proteins)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.
The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Proteins) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.
Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.
a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile
ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
, plasminogen activator, tissue type
, t-plasminogen activator
, tissue plasminogen activator (t-PA)
, tissue-type plasminogen activator
, tissue plasminogen activator
, T-plasminogen activator
, plasminogen activator, tissue
, tissue-type plasminogen activator-like