Browse our PLAT Proteins (PLAT)

Human Plasminogen Activator, Tissue (PLAT) interaction partners

1. PAI-1 (show SERPINE1 Proteins)/tPA ratio may be an important parameter to monitor the progression of OSMF, and normalizing this ratio to 1:1 may reinstate the normal healing pattern in OSMF cases

2. The concentration of tPA/PAI-1 (show SERPINE1 Proteins) complex is an independent predictor of mortality from all causes and from cardiovascular causes in patients with heart failure and preserved ejection fraction.

3. Underexpression of Tissue plasminogen activator is associated with diabetic foot syndrome.

4. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

5. Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen (show PLG Proteins) to efficiently generate plasmin (show PLG Proteins); this aggregate-bound plasmin (show PLG Proteins) is shielded from inhibition by alpha-2-antiplasmin (show Alpha2 Antiplasmin Proteins) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).

6. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

7. tPA is a ligand of the N-terminal domain of the obligatory GluN1 (show GRIN1 Proteins) subunit of NMDAR (show GRIN1 Proteins) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.

8. t-PA binds to Lys91 in the MBP (show MBL2 Proteins) NH2-terminal region and PLGbinds to Lys122 in the MBP (show MBL2 Proteins) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.

9. local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (show PLG Proteins) system toward the end of gestation. This may contribute to the ROM (show ROM1 Proteins) at both term and preterm birth.

10. We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) interaction partners

1. Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP (show LRP1 Proteins)/NF-kappaB (show NFKB1 Proteins)/Cox-2 in endothelial cells, endothelial MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion.

2. Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons.

3. analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations

4. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

5. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

6. A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).

7. While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.

8. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA

9. administration of ADAMTS13 (show ADAMTS13 Proteins) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Proteins) patency and consequently reduced cerebral infarct sizes

10. strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Proteins)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) interaction partners

1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

2. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth

3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Proteins) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) interaction partners

1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP