PLAT Protein (AA 33-559) (His tag)

Catalog No. ABIN7504552

Product Details

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Protein Type: Recombinant

Protein Characteristics: AA 33-559

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This PLAT protein is labelled with His tag.

Purpose: Mouse tPA Protein

Sequence: Ser33-Gln559

Characteristics: Recombinant Mouse tPA Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser33-Gln559, which consists of two chains: chain A (Ser33-Arg308) and chain B (Ile309-Gln559).

Purity: > 95 % as determined by Tris-Bis PAGE

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: tPA (PLAT Products)

Synonyms: T-PA Protein, TPA Protein, AU020998 Protein, AW212668 Protein, D8Ertd2e Protein, tPA Protein, PATISS Protein, tpa Protein, Plat Protein, plat Protein, t-pa Protein, plasminogen activator, tissue type Protein, plasminogen activator, tissue Protein, chromosome 20 open reading frame 181 Protein, plasminogen activator, tissue L homeolog Protein, PLAT Protein, Plat Protein, plat Protein, C20orf181 Protein, plat.L Protein

Background: Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.

Molecular Weight: 60.57 kDa. It migrates to 13-15 kDa (chain A and chain B fragment), 30-34 kDa and 35-40 kDa based on Tris-Bis PAGE result.

UniProt: P11214

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome