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anti-Human Vitronectin Antibodies:
anti-Mouse (Murine) Vitronectin Antibodies:
anti-Rat (Rattus) Vitronectin Antibodies:
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Human Monoclonal Vitronectin Primary Antibody for IA, FACS - ABIN2191905
Zanetti, Conforti, Hess, Martìn-Padura, Ghibaudi, Preissner, Dejana: Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane. in Blood 1994
Show all 2 Pubmed References
Human Polyclonal Vitronectin Primary Antibody for ELISA, IHC - ABIN4365584
Nyström, Thriene, Mittapalli, Kern, Kiritsi, Dengjel, Bruckner-Tuderman: Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms. in EMBO molecular medicine 2015
Show all 2 Pubmed References
Human Polyclonal Vitronectin Primary Antibody for IF (cc), IF (p) - ABIN675518
Wang, Jiang, Peng, Guo, Shang, Chen, Wu, Chen: Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates. in Biomaterials 2013
Human Monoclonal Vitronectin Primary Antibody for Inhibition, ELISA (Detection) - ABIN491687
Stefansson, Su, Ishigami, Cale, Gao, Gorlatova, Lawrence: The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin. in The Journal of biological chemistry 2007
Human Polyclonal Vitronectin Primary Antibody for FACS, IHC (p) - ABIN652347
Jenne, Stanley: Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion. in The EMBO journal 1986
Show all 4 Pubmed References
The 10 kDa C-terminal fragment of the ECM (show MMRN1 Antibodies) protein vitronectin (VTN) was then selected as a promising circulating biomarker in discriminating Nonalcoholic steatohepatitis.
The authors observed that exposure of Burkholderia pseudomallei and the closely related yet avirulent Burkholderia thailandensis to human plasma increased epithelial cell invasion by >20 fold. Receptor blocking studies with RGD-domain containing peptide and alphaV beta3 blocking antibody identified complement-activated vitronectin as the factor facilitating this invasion.
Additionally, the authors utilized vitroenctin-derived peptides to map the minimal Rickettsia conorii Adr1/human vitronectin interaction to the C-terminal region of vitronectin.
Serum vitronectin levels are elevated in human glioma, as well as are independently associated with pathologic grade based on WHO classification and 5-year poor prognosis. Moreover, this biomarker significantly discriminates gliomas from controls, other non-glioma brain tumors and other non-tumor neurological diseases, distinguishes high-grade gliomas from low-grade gliomas, and predicts 5-year progression and mortality.
Elevated serum VN levels represented high diagnostic value and had close relation to clinicopathological factors and early recurrence, suggesting that serum VN might be a useful diagnostic and prognostic marker for HCC (show FAM126A Antibodies).
We confirmed increased levels of C1R (show C1R Antibodies) and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses
This study examines the complexes of PAI-1 (show SERPINE1 Antibodies) with tissue-type and urokinase-type plasminogen activator (show PLAU Antibodies) and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
Ail-expressing Yersinia pestis strains bind vitronectin - a host protein with functions in cell attachment, fibrinolysis and inhibition of the complement system.
The mean level of PAI-1 (show SERPINE1 Antibodies) was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin was 83.10% +/- 23.77% (12%-126%) in the tumor group.
Bacterial protein-E (show CRISP1 Antibodies) and host vitronectin play a role in the attachment to bronchial epithelial cells and is also involved in the subsequent intracellular invasion of nontypeable Haemophilus influenzae.
The effects of genetic alterations in PAI-1 (show SERPINE1 Antibodies) expression, pharmacologic PAI-1 (show SERPINE1 Antibodies) inhibition and recombinant PAI-1 (show SERPINE1 Antibodies) on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1 (show SERPINE1 Antibodies)-deficient mice was assessed.
the TGF-beta (show TGFB1 Antibodies)-PAI-1 (show SERPINE1 Antibodies)-vitronectin-integrin axis may represent a critical convergence of factors in determining the alveolar epithelial cell apoptotic response during lung injury.
In vtn knockout mice, neuronal differentiation in the cerebellum was suppressed compared with wild-type mice.
Elevated levels of TIMP3 (show TIMP3 Antibodies) and vitronectin, acting downstream of Notch3 (show NOTCH3 Antibodies)(ECD (show ECD Antibodies)) deposition, play a role in CADASIL (show NOTCH3 Antibodies), producing divergent influences on early CBF (show CEBPZ Antibodies) deficits and later white matter lesions.
PAI-1 (show SERPINE1 Antibodies), through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI.
These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin (show FN1 Antibodies) fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin (show FN1 Antibodies) fibril extension.
Report role of vitronectin in the regulation of angiogenesis induced by VEGF (show VEGFA Antibodies).
Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
the extracellular matrix molecule VN and its neuronal receptor TLCN (show ICAM5 Antibodies) play a pivotal role in the phosphorylation of ezrin/radixin/moesin (show MSN Antibodies) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin (show CDH5 Antibodies) trafficking.
for intact vitronectin the effect of the heparin-binding domain predominates with respect to the signaling events that occur following ligand binding to the alphaVbeta3 integrin
These results imply that the amino acid motif RGD-2 of goat vitronectin is involved in complement C9 binding.
characterization of goat plasma vitronectin
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
, complement S-protein
, serum spreading factor
, serum-spreading factor
, somatomedin B
, vitronectin (serum spreading factor, somatomedin B, complement S-protein)
, glycoprotein 66
, complement S-protein)