Browse our anti-LRG1 (LRG1) Antibodies

Human Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) interaction partners

1. LRG-1 was highly expressed in human retinoblastoma sections, thus providing new insights into the molecular mechanism of retinoblastoma pathogenesis, and suggests a possible new therapeutic target.

2. The detection of LRG1 in accordance with the DeltaRct value (electron-transfer resistance at the electrode surface) of the sensor layer incorporating LRG1 BP3 peptides showed a statistically significant difference (p < 0.001) between adenomas and carcinomas, indicating that the potential use of this biosensing platform for detecting the CRC biomarker, as well as for monitoring the colorectal adenoma-to-carcinoma tra...

3. This study shows that TNF-alpha (show TNF Antibodies) is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.

4. the expression of 3 miRs and 9 mRNAs associate with the PIK3CA (show PIK3CA Antibodies) status. Expression of LRG1 is independent of luminal (A or B) subtype, decreased after neo-adjuvant aromatase (show CYP19A1 Antibodies) inhibitor treatment.

5. Plasma LRG1 predicts both albuminuria and Chronic kidney disease progression beyond traditional risk factors. It may play a role in the pathologic pathway leading to progression of diabetic kidney disease in T2 Diabetes mellitus.

6. LRG1 may be a key regulatory factor of allergic responses.

7. Results find serum LRG1 levels are significantly associated with LRG1 expression in gastric tumors. Its inhibition suppresses gastric cancer cell growth and invasion suggesting that LRG1 is implicating in gastric tumorigenesis.

8. LRG1 plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (show CALR Antibodies)) by regulating RUNX1 (show RUNX1 Antibodies) expression. LRG1 may be a potential detection biomarker as well as a marker for monitoring recurrence and therapeutic target for CRC (show CALR Antibodies).

9. These findings suggest that sputum LRG is a promising biomarker of local inflammation in asthma.

10. combination of modified whole blood LRG1 mRNA levels, plasma LRG1 protein and Alvarado score at the ED may be useful to diagnose simple and complicated acute appendicitis from other causes of abdominal pain

Mouse (Murine) Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) interaction partners

1. our data suggest that LRG promotes lung fibrosis by modulating TGF-beta (show TGFB1 Antibodies)-induced Smad2 (show SMAD2 Antibodies) phosphorylation and activating profibrotic responses in fibroblasts.

2. Our study indicates that LRG promotes the differentiation and the proliferation of Th17 in vivo and contributes to the development of collagen-induced arthritis

3. in vitro stimulation of mouse renal cortical tubular epithelial cells with excessive ALB (show ALB Antibodies) led to LRG mRNA up-regulation and its protein secretion, which was effectively blocked by IL-1 (show IL1A Antibodies) receptor antagonist. These results suggest that urinary LRG could be applied to a biomarker detecting renal tubular injury in various renal diseases.

4. Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age.

5. This study shows that TNF-alpha (show TNF Antibodies) is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.

6. findings reveal a novel and essential role of Lrig1 (show Lrig1 Antibodies) in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (show NTRK2 Antibodies) with Lrig1 (show Lrig1 Antibodies) represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (show BDNF Antibodies) during brain development

7. Loss of LRG is associated with Lewis lung carcinoma.

8. Human LRG (hLRG) concentration in the cerebrospinal fluid (CSF (show CSF2 Antibodies)) was measured and hLRG expression in post-mortem human cerebral cortex and mouse LRG (mLRG) in the brain were examined.

9. Mice lacking Lrg1 develop a mild retinal vascular phenotype but exhibit a significant reduction in pathological ocular angiogenesis.

10. cDNA clones for murine leucine-rich alpha2-glycoprotein were isolated. Expression of LRG during differentiation of 32Dcl3G cells preceded the expression of lactoferrin (show LTF Antibodies) and gelatinase but followed myeloperoxidase (show MPO Antibodies).