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COX-2 has been found to be overexpressed in Sinonasal Inverted Papilloma , and most likely plays an important role in the process of malignant transformation from Sinonasal Inverted Papilloma to Squamous Cell Carcinoma.
Expression of COX-2 in adenocarcinomas of the esophagogastric junction seems to have no prognostic effect or impact on patients' survival but is associated with favourable clinicopathologic factors
Topical application of glycolic acid suppresses the UVB induced IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), MCP-1 (show CCL2 Proteins) and COX-2 inflammation by modulating NF-kappaB (show NFKB1 Proteins) signaling pathway in keratinocytes.
the present study identified a positive correlation between EpCAM (show EPCAM Proteins) and COX-2 expression in breast cancer cell lines and tissue specimens. EpCAM (show EPCAM Proteins) and COX-2 were associated with the prognosis of breast cancer patients.
Intra-tumour activation of the PTEN/Akt (show AKT1 Proteins)/COX-2 pathway modulates colorectal cancer (CRC (show CALR Proteins)) progression and invasive capacity.
Tumor-infiltrating M2 macrophages could induce vasculogenic mimicry by up-regulating COX-2 expression in glioblastoma multiforme cells.
The results of this study show suppression of COX-2 in gingival tissue after low-level laser treatment as adjunct to scaling and root planing.
cyclooxygenase-2 is differentially expressed in metastatic melanoma, which has a role in progression free survival
Results show that overexpression of Aurora-A (show AURKA Proteins) and PTGS2 occurs in colon polyps and has a reverse correlation with miR (show MLXIP Proteins)-137 in both colon polyps and colorectal cancer tissue suggesting that AURKA (show AURKA Proteins) and PTGS2 expression is under the regulation of mir (show MLXIP Proteins)-137.
Studied role of HPV16 E6 and COX-2 in invasive ductal breast cancer using qPCR and IHC, and in vitro studies. Found HPV16 E6 promoted breast cancer proliferation; Cox-2 inhibition suppressed HPV16 E6 effects on proliferation thru NF-kappaB (show NFKB1 Proteins) signaling pathway.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (show IL1B Proteins),COX-2, and TGFbeta1 (show TGFB1 Proteins)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2.
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 vasodilator, prostacyclin.
Local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (show NFKB1 Proteins)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (show AVP Proteins) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (show IL1B Proteins)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (show EGF Proteins) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
Topical application of glycolic acid suppresses the UVB induced IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), MCP-1 (show CPT1B Proteins) and COX-2 inflammation by modulating NF-kappaB (show NFKB1 Proteins) signaling pathway in mouse skin.
COX-2/mPGES-1 (show PTGES Proteins)/PGE2 cascade activation mediates uric acid-induced glomerular mesangial cell proliferation.
Cobalt protoporphyrin induces COX-2 expression through activating P2X7 (show P2RX7 Proteins) receptors and ASK1 (show MAP3K5 Proteins)/MAP kinases as well as PIAS1 (show PIAS1 Proteins) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (show JUN Proteins) which, in turn, induces COX-2 expression.
Results indicate that Cox-2 promotes Col10a1 (show COL10A1 Proteins) expression and chondrocyte hypertrophy in vitro.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (show ROS1 Proteins) in macrophages.
Our data suggest that there are physiologically important gender differences in hypoxic acclimatization in COX-2-deficient mice. The COX-2 signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2-deficient mice may be able to access COX-2-independent mechanisms to achieve hypoxic acclimatization.
increased COX2 expression has an impact on the aging process
These results establish a novel signaling process whereby PAK1 (show PAK1 Proteins) upregulates COX-2, reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
Angiotensin II-AT1-receptor (show AGTRAP Proteins) signaling is necessary for COX-2-dependent normal postnatal nephrogenesis and maturation.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (show NR1D1 Proteins)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (show LTF Proteins), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2, and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Purinergic P2Y1 receptor (show P2RY1 Proteins) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (show MAPK1 Proteins) activation during the maturation process.
Inhibitors of c-Src (show SRC Proteins) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (show PGF Proteins)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (show CSF2 Proteins) during the peri (show PLIN1 Proteins)-attachment period in the cow.
This study showed that COX-1 (show PTGS1 Proteins) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Proteins)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (show OXTR Proteins), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (show PTGS1 Proteins) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (show MAPK14 Proteins) mitogen-activated kinase (MAPK (show MAPK1 Proteins)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (show CPOX Proteins)) gene expression in lipopolysaccharide (LPS (show IRF6 Proteins))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (show PTGS1 Proteins) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (show PTGS1 Proteins) and COX-2 is high in equine corneal SCC (show CYP11A1 Proteins), possibly indicating that COX (show CPOX Proteins) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like