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ADRB3 gene Trp64Arg mutation was significantly associated with an increased predisposition toward hypertension and elevated systolic/diastolic BP in hypertensive patients, suggesting that Trp64Arg is an important hypertension-susceptibility marker.
Studied weight loss in obese patients with Perilipin 4 (PLIN4 (show PLIN4 Proteins)), Fat mass and obesity-associated (FTO (show FTO Proteins)), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4 (show PLIN4 Proteins), FTO (show FTO Proteins), ADRB3 polymorphisms.
Middle-age adult Asians with the ADRB3 rs4994 minor alleles are at increased risk of Type 2 Diabetes (Meta-Analysis).
It has been shown, that presence of one mutant allele of rs9939609 (gene FTO (show FTO Proteins)) and rs4994 (gene ADRB3) leads to statistically significant association with obesity.
In mutant group of beta3 adrenoreceptor gene patients have higher insulin (show INS Proteins) and HOMA levels than wild type group, without relation with metabolic
Pharmacological experiments allowed us to demonstrate that these effects were driven by an Erk1/2-mediated activation of the antioxidant transcription factor PPARg (show PPARG Proteins). These results suggest that b3-AR protective effects in the myometrium could be due to its dual antioxidant properties.
The minor alleles of ADRB1 (show ADRB1 Proteins) and ADRB3 were significantly underrepresented in kinesiology students compared with nonmajors.
ADRB2 (show ADRB2 Proteins) Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition after controlled weight loss intervention.
body mass index (BMI) >/=25, PRRs of beta-3 adrenergic receptor genotype (Trp/Arg and Arg/Arg) for periodontal disease markers were 0.13 to 0.70, those of PPARgamma genotype (Pro/Pro) were 0.66 to 3.14 and those of the interaction term for the two genotypes were 1.69 to 12.61. Results confirm a positive relation between beta-3 adrenergic receptor genotype & PPAR-gamma genotype
Study reports association of the Arg64 allele of the rs4994 polymorphism of ADRB3 with increased serum urate in Western Polynesian individuals.
Specific visible radiation facilitates lipolysis in mature 3T3-L1 adipocytes via rhodopsin (show RHO Proteins)-dependent beta3-adrenergic signaling.
beta3-Adrenergic Regulation of EPC (show TCF21 Proteins) Features Through Manipulation of the Bone Marrow MSC (show MSC Proteins) Niche.
aerobic exercise training could improve cardiac systolic function and alleviate LV chamber dilation, cardiac fibrosis and hypertrophy in heart failure mice. The mechanism responsible for the protective effects of aerobic exercise is associated with the activation of the beta3-AR-nNOS (show NOS1 Proteins)-NO pathway.
Data (including data from studies in knockout mice) suggest that Adrb3 is dispensable for browning of adipose tissue; here, no differences was observed in cold-induced thermogenic gene expression in brown, white, or beige adipose tissues due to absence of Adrb3; irrespective of duration of cold exposure or sex of mice, no effect of absence of Adrb3 was observed.
injection of a b3-adrenergic receptor (b3-AR) agonist for continuous 5 days increased the number of Ki67 (show MKI67 Proteins)-positive brown adipocytes even at Day 1 but not that of SV cells. In addition, the b3-AR antagonist, but not b1-AR antagonist, attenuated the cold exposure-induced increase in the number of Ki67 (show MKI67 Proteins)-positive brown adipocytes
RIP140 (show NRIP1 Proteins) has a unique role in the acute effect of beta-3 adrenergic receptor activation.
Data show that fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of mitochondrial uncoupling protein 1 (show SLC25A19 Proteins) (UCP1 (show UCP1 Proteins)) and beta3 adrenergic receptor (beta3AR).
ADRB3 in perivascular adipose tissue contributes to vascular function in the progression of hypertension.
role of beta3-adrenoreceptor in myocardial infarction injury via eNOS (show NOS3 Proteins) and nNOS (show NOS1 Proteins) activation
Data suggest that Adrb3 is involved in regulation of pancreatic islet blood flow; hyperlipidemia (triglycerides and free fatty acids) is associated with vagus nerve-dependent increase in pancreatic/islet blood flow and up-regulation of insulin (show INS Proteins) secretion.
Variation in the promoter region of bovine ADRB3 was investigated.
small G protein (show RAC2 Proteins) Rac1 is a key regulator of beta(3)AR signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS (show NOS3 Proteins) pathways in the vascular wall
Coronary arteries possess functional beta(3)-adrenoceptors mediating endothelium- and NO-dependent relaxation. Celiprolol exerts a beta (show SUCLA2 Proteins)(3)-adrenoceptor agonistic activity in this vascular bed.
We suggest that ADRB3 polymorphism has the potential to be an important genetic marker for prediction of EMA (show ETFA Proteins) (eye muscle area)in Duroc pigs.
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
adrenergic, beta-3-, receptor
, beta-3 adrenergic receptor
, beta-3 adrenoceptor
, beta-3 adrenoreceptor
, Beta-3 AR
, Beta-3 adrenoceptor
, beta 3-AR
, beta3-adrenergic receptor
, adrenergic receptor, beta 3
, adrenergic, beta 3, receptor
, beta 3 adrenergic receptor
, beta-3-adrenergic receptor
, beta-3a-adrenergic receptor
, Beta-3 adrenoreceptor