Browse our anti-beta 2 Adrenergic Receptor (ADRB2) Antibodies

Zebrafish Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. Zebrafish larvae lacking beta1AR (show ADRB1 Antibodies) expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.

Mouse (Murine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility.

2. the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR (show ADRB1 Antibodies) TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.

3. S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (show SCP2 Antibodies)), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C Antibodies) and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.

4. activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP (show APP Antibodies) at Thr668

5. Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin (show INS Antibodies)-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes

6. beta2-AR deletion is associated to selective hepatic insulin (show INS Antibodies) resistance and preserved skeletal muscle insulin (show INS Antibodies) sensitivity.

7. The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.

8. knocking out of the beta1/2 (show TFAP2B Antibodies) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.

9. The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 (show CACNA1C Antibodies) upon beta-adrenergic stimulation rendering Cav1.2 (show CACNA1C Antibodies) refractory for several minutes from further beta-adrenergic stimulation.

10. The Galphas (show GNAS Antibodies) and Galphaq (show GNAQ Antibodies) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Antibodies), respectively. The beta2-AR/Galphas (show GNAS Antibodies) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Antibodies)/Galphaq (show GNAQ Antibodies) peptide interactions are predominantly hydrophobic.

Cow (Bovine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (show NR3C1 Antibodies) with neonatal glucose and lipid metabolism.

2. ADRb2 shows lipid scrambling activity.

3. relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R (show OXTR Antibodies)) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle

Human Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. Study analyzed dynamic behavior of 16 important residues in the binding pockets of beta2-adrenergic receptor bound with a variety of ligands, among which D1133.32 and N3127.39 are essential for ligand binding. The polar interactions with residues in TM5, particularly S2035.42 and S2075.46, are related to the agonistic properties, whereas hydrophobic interactions with residues in TM5 and TM6 help stabilize the receptor.

2. SNPs at codon 16 of the ADRB2 plays a role in the oxidative metabolic demand during exercise.

3. The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on exercise-induced bronchospasm. However, the statistical trend towards greater frequency of the Gly16 allele in individuals with exercise-induced bronchospasm can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents.

4. These data highlight a novel arrestin (show SAG Antibodies)-mediated modulation of CREB (show CREB1 Antibodies) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR to activate prolonged CREB (show CREB1 Antibodies) phosphorylation by precluding recruitment of an arrestin2/Src (show SRC Antibodies)/p38 (show CRK Antibodies) complex.

5. This systematic review and meta-analyses found that COPD (show ARCN1 Antibodies) risk and response to inhaled beta2-agonists were not associated with Thr164Ile, Arg16Gly, and Gln27Glu genotypes.

6. The discovery of B2AR as a new molecular marker of obesity subphenotypes in PBMCs might contribute to clarify the adrenergic immunomodulation of inflammatory obesity.

7. Genotypes at two variants of ADRB2 are associated with IAH. This association is comparable with the risk of classical risk factors for hypoglycemia .

8. beta2AR signaled through Galphas (show GNAS Antibodies) and Gbetagamma subunits through a pathway that involved the tyrosine kinase (show TXK Antibodies) SRC (show SRC Antibodies), the adaptor protein SHC (show SHC1 Antibodies), the guanine nucleotide exchange factor (show RASGRF1 Antibodies) SOS, the small GTPase (show RACGAP1 Antibodies) RAS, and the kinases RAF (show RAF1 Antibodies) and MEK (show MAP2K1 Antibodies), which led to ERK (show EPHB2 Antibodies) activation

9. these results indicate that stimulation of the beta2AR in osteoblasts triggers a Vegf (show VEGFA Antibodies)-dependent neo-angiogenic switch that promotes bone vascular density and the colonization of the bone microenvironment by metastatic breast cancer cells.

10. beta2AR is linked to transcription of alpha-synuclein and risk of Parkinson's disease in a ligand-specific fashion and constitutes a potential target for therapies.

Pig (Porcine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. The Galphas (show GNAS Antibodies) and Galphaq (show GNAQ Antibodies) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Antibodies), respectively. The beta2-AR/Galphas (show GNAS Antibodies) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Antibodies)/Galphaq (show GNAQ Antibodies) peptide interactions are predominantly hydrophobic.

2. A persistent B2R (show BDKRB2 Antibodies)-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA (show PLAT Antibodies).

3. Prolactin (show PRL Antibodies) infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway

4. Intracoronary intermedin (show ADM2 Antibodies) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (show CALCA Antibodies) receptors and beta-adrenoreceptor-mediated nitric oxide release.

Rhesus Monkey Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. The results imply ADRB-2-mediated actions in the development of primate follicles