Browse our anti-beta 2 Adrenergic Receptor (ADRB2) Antibodies

Zebrafish Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. Zebrafish larvae lacking beta1AR expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.

Mouse (Murine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. Findings reveal a critical role for ADRB2 signaling in controlling inflammation through the rapid induction of IL-10. Findings provide a fundamental insight into how the sympathetic nervous system controls a critical facet of immune function through ADRB2 signaling.

2. Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and beta2-adrenergic receptor in muscle and in a manner independent of muscle AMP-activated protein kinase.

3. Studies suggest role for beta-2 adrenoceptor (beta2-AR) in regulating cAMP intracellular levels that can modify suppressive function in T regulatory (TREG) cells.

4. these findings demonstrate an important role for host beta2AR signaling in suppressing T cell reconstitution and graft-versus-tumor activity.

5. Mechanistically, Adrb2 loss increases production of Vascular Endothelial Growth Factor-A (VEGF-A) in female neonatal beta-cells and results in hyper-vascularized islets during development, which in turn, disrupts insulin production and exocytosis.

6. betaeta 2-adrenergic receptor (beta2-AR) signaling can inhibit CD8(+) T-cell activation is by suppressing the required metabolic reprogramming events.

7. we identified the beta2 adrenergic receptor (ADRB2) as a downstream target for PHD3 in skeletal muscle

8. Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts.

9. Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility.

10. this review discusses beta2-adrenoceptor function in asthma

11. the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.

12. S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Cav1.2 and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.

13. activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP at Thr668

14. Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes

15. beta2-AR deletion is associated to selective hepatic insulin resistance and preserved skeletal muscle insulin sensitivity.

16. The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.

17. knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.

18. The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 upon beta-adrenergic stimulation rendering Cav1.2 refractory for several minutes from further beta-adrenergic stimulation.

19. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic.

20. Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function.

Cow (Bovine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism.

2. ADRb2 shows lipid scrambling activity.

3. relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle

4. of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)

5. beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance

Human Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. ADRB2 is negatively regulated by miR-15a-5p, which inhibits IL-13-induced nasal epithelial inflammatory responses.

2. Data show that an alanine mutant residue tyrosine 219 (Y219A) in transmembrane domain five of the beta2-adrenergic receptor (beta2AR) was incapable of beta-arrestin recruitment or receptor internalization.

3. Results have been able to identify how different phospholipids differentially modulate beta2AR activity as : partial inactivation, full deactivation or stable activation, and is seemingly governed by the chemistry of protein-interacting lipid headgroups.

4. Role of beta2-adrenergic receptor gene polymorphism (rs2400707) in fear and ecxtinction memory.

5. Authors conclude that the preferential mobilization of NK-cells, non-classical monocytes and differentiated subsets of CD8+ T-cells with exercise is largely dependent on catecholamine signaling through the beta2-AR.

6. this study shows that abnormal beta2-adrenoceptor phosphorylation in airway smooth muscle cells is present constitutively in cells from severe asthmatics

7. the data obtained in this study suggest that EHD1 plays a critical role in Non-small cell lung cancer (NSCLC) angiogenesis via b2AR signaling and highlight a potential target for antiangiogenic therapy.

8. findings suggest that the MBL2 and ADRB2 genes exert an important genetic influence on cystic fibrosis lung disease

9. The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the beta2-AR gene are associated with asthma severity and response to therapy.

10. preliminary evidence that beta2 -AR Arg16Gly genotype has a significant effect on fat-free mass, muscle strength and motor unit behaviour in humans.

11. PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma.

12. Polymorphism Gln27Glu of beta2 adrenergic receptors is associated with lower myocardial infarction rate.

13. adrenergic receptor polymorphism at codon 27 is not associated with asthma susceptibility in Egyptian children

14. The presence of the G allele and genotype G/G Gln27Glu of the ADRB2 gene are at risk for development and progression of obesity in patients with coronary heart disease.

15. Polymorphisms within ADRB2 as associated with increased risk of bronchial asthma in children and adolescents.

16. Arg16Gly polymorphism not associated with pulmonary response to asthma treatment with inhaled corticosteroids plus long-acting beta2-agonists [review]

17. We found that coronary artery disease patients harboring the ADRB2 rs1042714 Glu27 allele exhibited a positive association with cardiovascular events (risk ratio [RR] = 1.31, 95% confidence interval [CI]: 1.08-1.58, p = 0.006), but not with all-cause mortality (RR = 0.97, 95% CI: 0.70-1.35, p = 0.859).

18. Genetic polymorphism in ADRB2 is associated with risk of severe hypoglycemia in individuals with type 1 diabetes, especially in those with impaired hypoglycemia awareness.

19. An energy-restricted low-fat diet diet could be more beneficial than a moderately high protein diet to reduce serum cholesterol, LDL-c, and non-HDL-c among ADRB2 Gly16Gly genotype carriers.

20. Robust upregulation of cardiac galectin-3 (Gal-3) expression in a mouse model of cardiomyopathy attributable to cardiomyocyte-restricted transgenic activation of beta2-adrenoceptors may not be a critical disease mediator of cardiac remodeling in this model.

Pig (Porcine) Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic.

2. A persistent B2R-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA.

3. These data collectively reveal the potential of beta2ARag to improve skin scarring.

4. Beta(1)- and beta(2)-adrenoceptors contribute to the beta-feedforward coronary resistance vessel dilation during exercise.

5. Prolactin infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway

6. Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release.

Rhesus Monkey Adrenergic, beta-2-, Receptor, Surface (ADRB2) interaction partners

1. The results imply ADRB-2-mediated actions in the development of primate follicles