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anti-Human Galanin Receptor 1 Antibodies:
anti-Mouse (Murine) Galanin Receptor 1 Antibodies:
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Human Polyclonal Galanin Receptor 1 Primary Antibody for ELISA, WB - ABIN188719
Henson, Neubig, Jang, Ogawa, Zhang, Carey, DSilva: Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. in The Journal of biological chemistry 2005
Human Polyclonal Galanin Receptor 1 Primary Antibody for ICC, IHC (p) - ABIN271021
Barson, Chang, Poon, Morganstern, Leibowitz: Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat. in Neuroscience 2011
High methylation of GALR1 is associated with head and neck cancer.
Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder
GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis
Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
GALR1 methylation is associated with endometrial cancer.
Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer .
Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.
The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment.
it has been demonstrated that GalR1-5-HT1A receptors heteromerize.
disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation
The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents.
There was no effect of GALR1 on alcoholism risk.
Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein.
GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO
GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines.
GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition.
Galanin, acting via the GAL1 receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 and GIP secretion
endogenous Gal-1 may influence T. cruzi infection by fueling tolerogenic circuits that hinder anti-parasite immunity.
Experiments with a GalR1-preffering galanin analog, NAX-5055, show that GalR1 is involved in regulating glucose and insulin homeostasis
two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons.
GalR1 expression is increased in the nucleus accumbens after chronic restraint stress.
Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1
Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice
Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin-1 receptor expression.
Homozygous Galr1-/- mice are viable, capable of breeding, and exhibit no significant difference in growth rate. They have reduced circulating levels of insulin-like growth factor-I (IGF-I) and exhibit spontaneous tonic-clonic seizures.
The distribution of galanin receptor 1 messenger RNA in the mouse brain is abundantly expressed in many brain regions, including numerous hypothalamic and other forebrain regions associated with neuroendocrine function.
The duration of pain-like behaviours is significantly increased in mice lacking the galanin receptor 1 gene (Galr1-/-) after photochemically induced partial sciatic nerve ischemic injury.
Galanin receptor 1 knockout mice show increased anxiety-like behavior on the elevated plus-maze test, a finding that is consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor.
GAL-R1 knockout mice are unimpaired on a number of tests of learning and memory with the exception of the trace version of cued fear conditioning.
GalR1 mediate galanin protection from seizures and seizure-induced hippocampal injury in Li-pilocarpine and perforant-path- stimulation models of limbic status epilepticus, but not under conditions of kainic acid-induced seizures.
Increased levels of GalR1 mRNA and galanin binding (attributed to GalR1) in the external granule cell layer at P10-12/(14) coincide with granule cell migration from the external to the inner granule cell layer.
Changes in levels of GalR1 may play an important role in modulating signaling events and neuroplasticity underlying physiological functions of the locus coeruleus.
mice lacking the GALR1 receptor (Galr1-/-) exhibited only slight increase in heat nociception in the hot plate, but not tail flick, test and showed no increase in spinal sensitization
GalR1 knockout mice showed no difference with respect to acute nociception, but showed a modest tendency towards increased hyperalgesia after tissue injury and inflammation
Knockout mice deficient in the GAL-R1 receptor subtype were normal on most memory tasks, while showing a small deficit in trace cued fear conditioning
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
, galanin receptor type 1
, galanin receptor 1
, galactose operon repressor
, LacI family transcriptional regulatory protein