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anti-Human Galanin Receptor 1 Antibodies:
anti-Mouse (Murine) Galanin Receptor 1 Antibodies:
anti-Rat (Rattus) Galanin Receptor 1 Antibodies:
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Human Polyclonal Galanin Receptor 1 Primary Antibody for ELISA, WB - ABIN188719
Henson, Neubig, Jang, Ogawa, Zhang, Carey, DSilva: Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. in The Journal of biological chemistry 2005
Human Polyclonal Galanin Receptor 1 Primary Antibody for ICC, IHC (p) - ABIN271021
Barson, Chang, Poon, Morganstern, Leibowitz: Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat. in Neuroscience 2011
High methylation of GALR1 is associated with head and neck cancer.
Study provides evidence that GAL (show GAL Antibodies) and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
The MOR (show OPRM1 Antibodies)-Gal1R heteromer can explain previous results showing antagonistic galanin (show GAL Antibodies)-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder
GAL (show GAL Antibodies) and its receptors, GALR1 and GALR2 (show GALR2 Antibodies), play a role in head and neck squamous cell carcinoma tumorigenesis
Variants in genes for galanin (GAL (show GAL Antibodies)) and its receptors (GALR1, GALR2 (show GALR2 Antibodies), GALR3 (show GALR3 Antibodies)), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
GALR1 methylation is associated with endometrial cancer.
Moreover, we have identified a novel role for the GalR1/galanin (show GAL Antibodies) receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer .
Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.
The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment.
it has been demonstrated that GalR1-5-HT1A (show HTR1A Antibodies) receptors heteromerize.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 (show CNR1 Antibodies) receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD Antibodies) muscarinic receptor (show CHRM5 Antibodies) subtypes was also analyzed in brain areas involved in anxiety and cognition.
Galanin (show GAL Antibodies), acting via the GAL1 (show LGALS1 Antibodies) receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 (show GCG Antibodies) and GIP (show GIP Antibodies) secretion
endogenous Gal-1 (show LGALS1 Antibodies) may influence T. cruzi infection by fueling tolerogenic circuits that hinder anti-parasite immunity.
Experiments with a GalR1-preffering galanin (show GAL Antibodies) analog, NAX (show SCN7A Antibodies)-5055, show that GalR1 is involved in regulating glucose and insulin (show INS Antibodies) homeostasis
two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons.
GalR1 expression is increased in the nucleus accumbens after chronic restraint stress.
Galanin (show GAL Antibodies) opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1
Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice
Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin (show GAL Antibodies)-1 receptor expression.
Homozygous Galr1-/- mice are viable, capable of breeding, and exhibit no significant difference in growth rate. They have reduced circulating levels of insulin-like growth factor-I (IGF-I (show IGF1 Antibodies)) and exhibit spontaneous tonic-clonic seizures.
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
, galanin receptor type 1
, galanin receptor 1
, galactose operon repressor
, LacI family transcriptional regulatory protein