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rs712723 in GRM8 was selected for genotyping. The allele C and genotype CC (allele C: OR 1.48, 95% CI 1.13-1.94; genotype CC: OR 1.71, 95% CI 1.09-2.68) of rs712723 polymorphism was found to have a significant association with risk of schizophrenia while allele T (P = 0.003) and genotype TT (P = 0.028) frequencies were found lower in control patients.
This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence).
Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population
These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region.
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8).
The GRM8 gene might play an important role in the pathogenesis of schizophrenia.
Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain
Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
Pias1 binds to and sumoylates metabotropic glutamate receptor 8
Polymorphism not associated with panic disorder.
GRM8 genes are likely involved in the pathogenesis of autistic disorder.
Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported.
the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression
In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway.
mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress.
mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice.
Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear.
The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods.
Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice.
The increased anxiety-related behavior of mGlu8 receptor knockout mice in the elevated plus maze is associated with an increased number of c-Fos positive cells in the centromedial nucleus of the thalamus compared with wild-type mice.
Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.
mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL; mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
metabotropic glutamate receptor 8
, metabotropic type glutamate receptor 8
, glutamate receptor, metabotropic 8
, G protein coupled receptor, family C, group 1, member H
, G protein-coupled receptor, family C, group 1, member H
, G protein-coupled receptor family C group 1 member H
, metabotropic glutamate receptor subtype 8b