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this study shows that sensory axon bifurcation is insensitive to increases of C-type natriuretic peptide induced cyclic GMP levels and the guanylate cyclase receptor Npr3 does not have an important scavenging function in this axonal system.
A model of kyphosis due to a novel NPR3 Tyr209Asn mutation is established.
Npr3 is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Proteins) signaling in fracture repair, especially in bone remodeling stage.
NPR-C is required to control DNA damage-induced p53 (show TP53 Proteins) levels to maintain embryonic stem cell self-renewal.
Results demonstrate the opposite effects of NPR-A (show NPR1 Proteins) and NPR-C in LPS (show TLR4 Proteins)-mediated endothelial permeability and lung injury.
A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies Npr3 as novel candidate obesity genes.
Upregulation of NPR-C mRNA in the kidney and heart of eNOS (show NOS3 Proteins) knockout mice.
CNP (show CNP Proteins) has negative chronotropic effect on heart rate, and this effect is mediated by selectively activating NPR-C and reducing L-type Ca2 (show CA2 Proteins)+ current through coupling to Gi protein.
circulating ANP (show NPPA Proteins) levels and data from NPR1 (show NPR1 Proteins)(-/-) and NPR3(-/-) mice suggest that the ANP (show NPPA Proteins) pathway may not be involved in the cardiovascular response to caloric restriction
discussion of neuronal regulation and function of natriuretic peptide receptor C [review]
This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP (show NPPA Proteins) level.
NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population
The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension.
This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai (show ZBP1 Proteins) and 484 Chinese Mongolian individuals.
Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA.
Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease.
Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides.
The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation.
polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population.
a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
, Nppc receptor
, atrial natriuretic peptide clearance receptor
, atrial natriuretic peptide receptor 3
, atrial natriuretic peptide receptor type C
, Atrial natriuretic peptide clearence receptor 3
, atrial natriuretic peptide C-type receptor
, natriuretic peptide receptor 3
, atrionatriuretic peptide receptor C
, natriuretic peptide receptor C