NPR3 Protein (Fc Tag)

Catalog No. ABIN7319905

This Recombinant NPR3 protein is produced in Human Cells.

Quick Overview for NPR3 Protein (Fc Tag) (ABIN7319905)

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This NPR3 protein is labelled with Fc Tag.

Purpose: Recombinant Human NPRC/NPR3 (C-Fc)

Sequence: Thr24-Glu481

Characteristics: Recombinant Human Atrial Natriuretic Peptide Receptor 3 is produced by our Mammalian expression system and the target gene encoding Thr24-Glu481 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Alternative Name: NPRC/NPR3

Background:

Background: Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.

Synonym: ANP-C, ANPR-C, NPR3, NPRC, NPR-C,ANPRC, C5orf23

Molecular Weight: 77.5 kDa

UniProt: P17342

Pathways: cAMP Metabolic Process