Browse our CD276 Proteins (CD276)

Cow (Bovine) CD276 Molecule (CD276) interaction partners

1. Anterior pituitary gland progenitor cells containing 4Ig-B7-H3 (CD276) may play a critical role in the immunoendocrine network.

Mouse (Murine) CD276 Molecule (CD276) interaction partners

1. These results indicated an important role for B7-H3 in the development of Th1 and Th2 cells in a murine model of asthma and its proinflammatory effects are not dependent on TLR2 signaling.

2. These results demonstrate that B7H3 substantially ameliorates LPS-induced Acute lung injury and this protection afforded by B7H3 is predominantly associated with its inhibitory effect on pulmonary PMN migration and infiltration

3. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

4. blockage of NF-kappaB p65 and/or MAPK p38 with their specific inhibitors strongly attenuated B7-H3-amplified inflammatory response with significantly reduced proinflammatory cytokine and chemokine production, and markedly ameliorated B7-H3-exacerbated disruption of blood-brain barrier and severity of disease status in S. pneumoniae-infected mice.

5. CD276 is broadly expressed by tumor cells and tumor vasculature but Is dispensable for tumor growth.

6. this study shows that B7-H3 participates in the development of acute pancreatitis

7. Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.

8. Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

9. Murine B7-H3 is a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.

10. B7-H3 inhibits T cell proliferation. FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules

11. The study investigates the role of B7-H3 in pancreatic cancer progression and shows that this protein promotes cancer cell migration and invasiveness in vitro and in vivo.

12. Graft prolongation achieved by CTLA4 Ig was shortened both by B7-H3 blockade and the absence of recipient B7-H3.

13. Macrophage-tumor cell interaction-induced membrane-bound B7-H3 represents a novel immune escape mechanism which links the pro-inflammatory response to immune tolerance in the tumor milieu.

14. Exogenous administration of B7-H3 strongly amplifies the inflammatory response, exacerbates blood-brain barrier disruption, and aggravates the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN wild-type mice.

15. Tumour-associated B7-H3 directly augments CD8(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.

16. preferentially down-regulates t helper type 1-mediated immune responses

17. B7-H3 serves as a negative regulator of T cell activation and function

18. Plays a positive regulatory role in bone formation. In addition, has a dual role in the bone-immune interface.

19. A role is established for B7-H3 in the costimulation of T cell-mediated tumor immunity in vivo.

20. Dendritic cells expressing soluble mB7h3-hIg showed a significant reduced allo-stimulatory capability compared with controls. Soluble mB7h3-hIg also inhibited IL-2 and IFN-gamma production of allogenic T cells, suggesting therapeutic potential

Human CD276 Molecule (CD276) interaction partners

1. The expression of B7-H3 and B7-H4 favored an immunosuppressive microenvironment by promoting the production of IL-10 and TGFB1, thereby resulting in progression of cervical carcinogenesis.

2. miR-506 functions as a tumor suppressor miRNA and plays a significant role in inhibiting human mantle cell lymphoma cell proliferation and metastasis by suppressing B7H3 expression.

3. High CD276 expression is associated with multiple myeloma.

4. the importance of BRD4/B7-H3/TLR4 pathway

5. Expression of B7H3 and B7H4 is closely corelated with clinicopathological parameters and prognosis of patients with T-LBL/ALL, suggesting that B7H3 and B7H4 expression play an important role in the development of T-LBL/ALL.

6. HIV-infected lung cancer patients had significantly higher tumor B7-H3 expression compared to HIV-uninfected controls, and importantly similar tumor PD-L1 expression, and PD-1and PD-L1 expression on TII.

7. Overexpression of B7H3 contributes to malignant biliary strictures.

8. Evidence for B7-H3 mediating tumor glycolysis, via interacting with ENO1.

9. The axis of miR-29c/B7-H3 plays an important role in children with asthma through regulating Th2/Th17 cell differentiation and may provide new targets for treatment of asthma.

10. Study using human melanoma skin samples and keratinocytes primary and cell line culture suggest that a basal expression of B7-H3 on keratinocytes may contribute to a constitutive immunological function of human epidermis.

11. Increased B7 protein expression by infiltrating immune cells was associated with disease progression, and specifically, the level of B7-H3 expression and localization of B7-H4 expression differed significantly among different stages of gastric carcinogenesis.

12. B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhancing B-RAF and MEK interaction. B7-H3 expression increases stem cell population by binding to MVP which regulates the activation of the MAPK kinase pathway. Depletion of MVP blocks the activation of MEK induced by B7-H3 and dramatically inhibits B7-H3 induced stem cells.

13. B7-H3 might be an independent risk factor for 5-year mortality for Congenital Heart Disease (CHD) patients. Serum levels of B7-H3 were related to long-term major cardiovascular events and 5-year mortality of CHD patients.

14. Study indicates that breast cancer patients have detectable circulating epithelial tumor cells (CETCs) with a high frequency of B7-H3 expression regardless of the stage of the disease. B7-H3 seems to be an important factor in immune evasion and may thus be a promising target for anticancer therapies.

15. it is likely that B7-H3 plays an important role in cancer diagnosis and treatment, aside from its role as a co-stimulatory molecule--{REVIEW}

16. High B7-H3 expression is associated with phyllodes tumors.

17. characterization of the expression pattern and biological function of B7-H3 in brain gliomas; B7-H3 expression is regulated by multiple mechanisms and is potentially involved in the T-cell receptor signaling pathway; higher B7-H3 expression indicates a worse prognosis for glioma patients

18. High expression level of B7H3 in muscleinvasive bladder cancer (MIBC) tissues is associated with a poor clinico-pathological status and poor prognosis, and promotes the development of MIBC in vitro and in vivo.

19. Tumor B7-H3 expression was significantly higher in immunocompetent vs. immunosuppressed patients, largely driven by very low expression in HIV+ patients.

20. Colorectal cancer (CRC) patients expressing both high B7-H3 and high B3GALT4 contributed to a significant decrease in overall survival. The expression of B3GALT4 in CRC is positively correlated with B7-H3 expression in vitro. B7-H3/B3GLAT4 may be used as dual prognostic biomarkers for CRC.