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anti-Mouse (Murine) GAS2 Antibodies:
anti-Human GAS2 Antibodies:
anti-Rat (Rattus) GAS2 Antibodies:
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Human Polyclonal GAS2 Primary Antibody for ELISA, WB - ABIN560999
Kondo, Shen, Cheng, Ahmed, Boumber, Charo, Yamochi, Urano, Furukawa, Kwabi-Addo, Gold, Sekido, Huang, Issa: Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. in Nature genetics 2008
Human Monoclonal GAS2 Primary Antibody for IF, ELISA - ABIN561000
Petroulakis, Parsyan, Dowling, LeBacquer, Martineau, Bidinosti, Larsson, Alain, Rong, Mamane, Paquet, Furic, Topisirovic, Shahbazian, Livingstone, Costa-Mattioli, Teodoro, Sonenberg: p53-dependent translational control of senescence and transformation via 4E-BPs. in Cancer cell 2009
GAS2 is a critical and novel regulator of tissue remodeling in the ovary during oocyte cyst breakdown and folliculogenesis
these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro.
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
This study found a highly significant correlation between colorectal cancers relapse and growth arrest-specific 2 (GAS2) gene expression. Based on cell models, the overexpressed GAS2 was associated with cellular growth rate, cell cycle regulation, and with chemotherapeutic sensitivity.
Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells.
Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling.
GAS2 is up-regulated in chronic myeloid leukemia cells.
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia.
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
growth arrest-specific protein 2
, growth arrest-specific 2