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anti-Mouse (Murine) GAS2 Antibodies:
anti-Human GAS2 Antibodies:
anti-Rat (Rattus) GAS2 Antibodies:
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Human Polyclonal GAS2 Primary Antibody for ELISA, WB - ABIN560999
Kondo, Shen, Cheng, Ahmed, Boumber, Charo, Yamochi, Urano, Furukawa, Kwabi-Addo, Gold, Sekido, Huang, Issa: Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. in Nature genetics 2008
Human Monoclonal GAS2 Primary Antibody for IF, ELISA - ABIN561000
Petroulakis, Parsyan, Dowling, LeBacquer, Martineau, Bidinosti, Larsson, Alain, Rong, Mamane, Paquet, Furic, Topisirovic, Shahbazian, Livingstone, Costa-Mattioli, Teodoro, Sonenberg: p53-dependent translational control of senescence and transformation via 4E-BPs. in Cancer cell 2009
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin (show CTNNB1 Antibodies)
Taken together, our results demonstrated the deregulation of GAS2 in both AML (show RUNX1 Antibodies) and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells.
Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 (show TP53 Antibodies) signaling.
GAS2 is up-regulated in chronic myeloid leukemia (show BCL11A Antibodies) cells.
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP (show IRF8 Antibodies) influences beta-catenin (show CTNNB1 Antibodies) activity in myeloid leukemia (show BCL11A Antibodies).
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
growth arrest-specific protein 2
, growth arrest-specific 2