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Full name:: Spectrin alpha Chain, Brain Proteins (SPTAN1)

On www.antibodies-online.com are 30 Spectrin alpha Chain, Brain (SPTAN1) Proteins from 4 different suppliers available. Additionally we are shipping SPTAN1 Antibodies (155) and SPTAN1 Kits (25) and many more products for this protein. A total of 217 SPTAN1 products are currently listed.

Synonyms:: 2610027H02Rik, A2a, EIEE5, im:7157190, IPF, NEAS, SPECA, Spna-2, Spna2, SPTA2, wu:fa20e05, wu:fb33g08, wu:fk32a10, zgc:112229

list all proteins	Gene Name	GeneID	UniProt
	SPTAN1	20740
	SPTAN1	6709	Q13813
	SPTAN1	64159	P16086
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Zebrafish Spectrin alpha Chain, Brain (SPTAN1) interaction partners

AlphaII-spectrin in the axonal cytoskeleton is essential for stabilizing nascent sodium-channel clusters and assembling the mature node of Ranvier.

Mouse (Murine) Spectrin alpha Chain, Brain (SPTAN1) interaction partners

Fodrin is a regulatory transporter of gamma-tubulin (show TUBG1 Proteins) to the centrosomes for normal progression of mitosis.
Mena/VASP and alphaII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.
Degradation of Spna2 by calpain- and/or caspase is not central to the pathogenesis of 1,2-diacetylbenzene (DAB) axonopathy.
The present study demonstrates the age-dependent intraneuronal presence of an alphaII-spectrin cleavage fragment in mammalian forebrain which is exacerbated in a transgenic model of AD.
alphaII-spectrin deficiency is embryonic lethal, with cardiac, craniofacial and neural tube malformations.
Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.
When cleaved into a 120-kDa product by apoptotic proteases in salivary gland cells in vitro, alpha-fodrin is a successful pathogenic autoantigen for development of autoimmune exocrinopathy in the Sjogren syndrome model.
In heart muscle, alphaII-spectrin is located within the contractile fibres near the Z-disc as well as on the cardiomyocyte plasma membrane.
support a critical role for the alphaII-spectrin-SH3i isoform of spectrin in intracellular targeting of connexin 43 (show GJA1 Proteins) to gap junctions
AlphaII-spectrin-VASP complexes regulate cortical actin cytoskeleton assembly with implications for vascular permeability.

Human Spectrin alpha Chain, Brain (SPTAN1) interaction partners

Spectrin may be engaged in regulation of distinct events necessary for the establishment and maturity of the immunological synapse.
SPTAN1-related disorders comprise a wide spectrum of neurodevelopmental phenotypes ranging from mild to severe and progressive. Spectrin aggregate formation in fibroblasts with mutations in the alpha/beta heterodimerization domain seems to be associated with a severe neurodegenerative course.
Alpha-spectrin is critical for recruitment of non-ubiquitinated FANCD2 to sites of damage, which has an important role in the repair response and interstrand cross-link repair.
These results suggest that ubiquitin C-terminal hydrolase and alphaII-spectrin breakdown product 145 kDa may be useful in assessing outcome after pediatric traumatic brain injury.
Variations in both alpha-spectrin (SPTA1) and beta-spectrin ( SPTB ) were found in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.
aggressiveness of MLH1 (show MLH1 Proteins)-positive colorectal cancers might be related to SPTAN1.
hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed
loss of SPTAN1 switches TGF-beta (show TGFB1 Proteins) signaling from tumor suppression to tumor promotion by engaging Notch (show NOTCH1 Proteins) signaling and activating SOX9 (show SOX9 Proteins) in esophageal adenocarcinoma.
organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (show PKCd Proteins)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin
In-frame mutations in the C-terminus of SPTAN1 cause a core set of manifestations that include severe intellectual disability, generalized epilepsy, and pontocerebellar atrophy.

SPTAN1 Protein Profile

Protein Summary

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with SPTAN1

spectrin alpha, non-erythrocytic 1 (SPTAN1)
spectrin alpha, non-erythrocytic 1 (sptan1)
spectrin alpha, non-erythrocytic 1 (Sptan1)
spectrin, alpha, non-erythrocytic 1 (Sptan1)

2610027H02Rik protein
A2a protein
EIEE5 protein
im:7157190 protein
IPF protein
NEAS protein
SPECA protein
Spna-2 protein
Spna2 protein
SPTA2 protein
wu:fa20e05 protein
wu:fb33g08 protein
wu:fk32a10 protein
zgc:112229 protein

Protein level used designations for SPTAN1

, , , , , , , , , , , , , , , , , , , , , , alpha-fodrin spectrin alpha chain, brain spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) cardiomyocyte alpha-spectrin sequence with a GC signal alpha2 spectrin Spectrin alpha chain, brain alpha-II spectrin alpha-spectrin 2, brain fodrin alpha chain spectrin alpha 2 spectrin alpha chain, non-erythrocytic 1 spectrin, non-erythroid alpha chain spectrin, non-erythroid alpha subunit a--fodrin alpha II spectrin alpha-spectrin 2 brain alpha-spectrin inhibitory protein factor noerythroid alpha-spectrin 2 nonerythroid alpha-spectrin 2 alpha-spectrin nonerythroid alpha-spectrin

GENE ID	SPECIES
540108	Bos taurus
403484	Canis lupus familiaris
553383	Danio rerio
100380773	Salmo salar
20740	Mus musculus
6709	Homo sapiens
64159	Rattus norvegicus
374234	Gallus gallus

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