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B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
In a model of human epilepsy, topo I shows a novel function in construction and/or maintenance of circuits required for seizure propagation in vivo.
TOP1alpha is required for the survival of stele stem cells and regulates the differentiation state and number of columella stem cells.
TOP1ALPHA role in flowering
Pleiotropic effect of the fas5 mutation on different stages of ontogeny and different organs suggests that the FAS5 gene plays a complex regulatory role at all stages of the A. thaliana shoot development. [Fas5]
In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy.
Further studies with Arabidopsis top1alpha mutants showed that TOP1alpha silences endogenous RdDM loci by facilitating the production of Pol V-dependent long non-coding RNAs, AGONAUTE4 recruitment and H3K9me2 deposition at TEs and repeats
MGO1 encodes a putative Arabidopsis type IB topoisomerase that functions together with WUS in stem cell regulation. [MGO1]
While TOP-1alpha isoform has tissue specificity, the TOP-1beta isoform is expressed in most tissues and cells. RNAi targeted to both TOP-1 isoforms demonstrated that TOP-1 is required for chromosomal segregation, germline proliferation and gonadal migration.
Topo I overexpression is observed in a significant subset of laryngeal squamous cell carcinoma affecting the level of differentiation in them.
Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB.
TOPO1 expression was prevalent in SCLC patients. Strong expression was associated with an elevated disease control rate after second-line topotecan chemotherapy. Patients with sensitive disease that relapsed after first-line chemotherapy had better survival than refractory patients who received second-line topotecan chemotherapy.
High expression of TOPO-1 and CES-2 are correlated with longer progression free and overall survival in irinotecan treated metastatic colorectal cancer patients.
TOP1 is highly expressed in liver cancer tissues and acts as an oncogene.
results demonstrate that the interaction between NORAD (a specific long non-coding RNA-non-coding RNA activated by DNA damage) and RBMX is important for NORAD function; and that NORAD is required for the assembly of the previously unknown topoisomerase complex NARC1, which contributes to maintaining genomic stability
TOP1 differentially modulates R-loops across the human genome.
Results from a study on gene expression variability markers in early-stage human embryos shows that TOP1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
High TOP1 expression is associated with aggressive tumor phenotype in breast cancer.
Ru/Fe bimetallic complexes: Synthesis, characterization, cytotoxicity and study of their interactions with DNA/HSA and human topoisomerase IB.
two regions of topoisomerase I, the N-terminal and the linker domains, were critical for subnuclear localization of the enzyme. The linker domain and the distal region of the N-terminal domain directed topoisomerase I to the nucleolus, whereas the remaining region of the N-terminal domain was responsible for the nucleoplasmic localization.
High TOP1 expression is associated with Colorectal Cancers.
HMGA2 potentiates the clinically important topoisomerase I inhibitor irinotecan/SN-38 in trapping the enzyme in covalent DNA-complexes, thereby attenuating transcription.
IMMP2L transcription requires Topoisomerase I in human primary astrocytes
This work identifies ADP-ribose polymers as key determinant for regulating Top1 subnuclear dynamics.
copper(II) thiosemicarbazone complex may hit human topoisomerase IB and that metal coordination can be useful to improve cytotoxicity of this versatile class of compounds
High prevalence of anti-topoisomerase I antibody positivity was found among Thai systemic sclerosis patients and this was associated with a high frequency of hand deformity, ACA negativity, a short duration of pulmonary fibrosis in diffuse cutaneous and a lower frequency of Raynaud's phenomenon in limited cutaneous subsets.
These findings reveal BAZ1B as a key facilitator of topoisomerase I function during DNA replication that affects the response of cancer cells to topoisomerase I inhibitors.
Results identified TOP1 gene copy gain, a loss of chromosome 20, and new yet unreported TOP1 mutations (R364K and G717R) in close proximity to the SN-38 binding site conferring colon cancer cells resistance to the drug.
the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum
treatment of topotecan, a brain-penetrating topoisomerase 1 inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities. Finally, we show that topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin, but also at the same time induces the expression of Ube3a
It has been shown that the livers of Sprtn deficient mice accumulate DNA-protein crosslinks containing Topoisomerase 1 covalently linked to DNA.
TOP1cc-dependent and -independent contributions to gene expression
this study identified topoisomerase 1 as a cardinal Aire partner that colocalized on super-enhancers and was required for the interaction of Aire with all of its other associates
Data indicate that mitochondrial topoisomerase I (TOP1mt) knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation.
Topoisomerase I deficiency in B cells is associated with RNA polymerase II accumulation, recruitment of activation-induced deaminase (AID) to immunoglobulin variable genes and the mechanism for increased diversity of these genes.
Findings suggest that topoisomerase 1 (TOP1) controls the levels of multiple synaptic proteins and is required for normal excitatory and inhibitory synaptic transmission.
Top1mt accumulates in the regulatory region of mitochondrial DNA.
our data implicate Top1mt for mitochondrial integrity and energy metabolism.
model in which small molecule inhibitors convert PARP1 into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.
AID-induced Top1 reduction alters S region DNA structure probably to non-B form, on which Top1 can introduce nicks but cannot religate, resulting in S region cleavage.
The contributions of strong and week nonspecific electrostatic, van der Waals's, and hydrophobic interactions, and hydrogen bonding of the enzymes to the complex formation with the single- and double-stranded DNAs were determined.
Several alternatively spliced genes, characterized by small exons and large introns, are down-regulated in Topo I-deficient p388 leukemia cells.
topoisomerase I-mediated DNA damage and cell death is induced by hydrogen peroxide
analysis of the ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes
findings show that the neurotransmitters glutamate and gamma-aminobutyric acid (GABA) regulate the activity of topo I in mouse cerebellum sections
These results indicate that TopoI is expressed in an autonomous circadian rhythm in NIH3T3 cells.
DNA topoisomerase 1, exposed to a specific oxidation, is not only the target of the immune response in systemic sclerosis but is a crucial factor responsible for the diffusion of oxidative stress and induction of tissular damage in a mouse model.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
, topoisomerase 1
, topoisomerase I
, type I topoisomerase
, DNA topoisomerase I
, DNA topoisomerase 1
, type I DNA topoisomerase