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Endothelial Cx40 contributes to the early stages of physiological angiogenesis in the developing retina, by regulating vessel growth and maturation.
Cx40 may participate in compromised endothelial electrical couplilng response in the microvasculature during sepsis.
We also detected a significant decrease in the concentration of mitochondrial reactive oxygen species (ROS (show ROS1 ELISA Kits)) in Cx40 KO MCECs. Cx40 overexpression in ECs significantly increased resting [Ca(2 (show CA2 ELISA Kits)+)]mito level and calcium uptake by mitochondria in response to increased [Ca(2 (show CA2 ELISA Kits)+)]cyto and augmented mitochondrial ROS (show ROS1 ELISA Kits) production. These data suggest that mitochondrial Cx40 contributes to the regulation of mitochondrial calcium homeos
intermittent hypoxia (but not sleep fragmentation) causes reductions and remodeling of atrial Cx40 and Cx43 (show GJA1 ELISA Kits).
High-fat diet increases vulnerability to atrial arrhythmia by down-regulation of Cx40 via miR (show MLXIP ELISA Kits)-27b.
Report interaction between ALK1 (show ACVRL1 ELISA Kits) signaling and connexin40 in the development of arteriovenous malformations.
Cx40 is a requirement for the pressure control of renin (show REN ELISA Kits) secretion irrespective of the localization of renin (show REN ELISA Kits) secreting cells.
Cx37 (show GJA4 ELISA Kits) is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40.
This study showed the progressive changes of Cx 40 at protein and mRNA levels in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Cx40 and Cx37 (show GJA4 ELISA Kits) play an in vivo role in the regulation of eNOS (show NOS3 ELISA Kits).
Cx40 genetic polymorphisms increase atrial fibrillation risk in Uyghur and Han residents of Xinjiang.
Cx 40 (rs35594137) was associated with atrial fibrillation; in the Uygur population, Cx 40 (rs35594137) should be considered as an independent risk factor for patients with atrial fibrillation, who might have racial differences in rs35594137 variant frequencies
This is a review summarizing atrial fibrillation-linked somatic and germline mutations in the gene encoding Cx40. Multiple impairments were observed in these mutants, including impaired gap junction function by abnormal localization or function, as well as increased hemichannel function.
Human atrial myocytes express Cx40 and Cx43 (show GJA1 ELISA Kits). However, in vitro expression study indicates that human Cx40 is not able to dock with Cx43 (show GJA1 ELISA Kits) to form heterotypic gap junction channels. This study designed two Cx40 variants, D55N or P193Q. Both of them were successful in forming functional heterotypic gap junction channels with Cx43 (show GJA1 ELISA Kits).
Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.
Reduced Cx40 levels and heterogeneity of its distribution (relative to Cx43 (show GJA1 ELISA Kits)) are common in atrial fibrillation.
Two atrial fibrillation-linked germline Cx40 mutants, V85I and L221I, were investigated.
These findings provide evidence that the connexin 40 Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of atrial fibrillation.
17-beta-estradiol modulates connexins and integrins as well as ER-beta (show ESR2 ELISA Kits) expression induced by high frequency electromagnetic fields.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.
, gap junction alpha-5 protein
, gap junction membrane channel protein alpha 5
, gap junction protein alpha 5
, gap junction protein, alpha 5, 40kDa (connexin 40)