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Human ITGB1 Protein expressed in Wheat germ - ABIN2752830
Ahn, Mohamedali, Anand, Cheruku, Birch, Sowmya, Cantor, Ranganathan, Inglis, Frank, Agrez, Nice, Baker: Characterization of the interaction between heterodimeric ?v?6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. in Journal of proteome research 2014
Findings demonstrate the neurotrophin (show BDNF Proteins), BDNF (show BDNF Proteins)-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .
Findings identify beta(1)-integrin as an important functional cargo during Ca(2+)-dependent rapid endocytosis stimulated by a diffusible guidance cue in Xenopus spinal neurons.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin (show FN1 Proteins) both in vitro as well as in vivo.
Integrin beta1 and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization.
The results of this study suggest that the effects of beta1-integrin gene knockout on these results suggest that the effects of beta1-integrin gene knockout on NSC maintenance and fate commitment in the DG follow a substantially slower time course in males compared to females because of increased persistence of beta1-integrin protein in males.
results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 (show RUNX2 Proteins) through alpha5beta1 integrin /ERK (show EPHB2 Proteins) pathway
the cross-talk between SFRP4 (show SFRP4 Proteins), integrin alpha1beta1, and Notch1 (show NOTCH1 Proteins) suppresses the cardiac differentiation of P19CL6 cells.
Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.
We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling
Itgb1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of Sharpin-deficient mice.
Taken together, acid-induced acute lung injury results in epithelial microvesicle shuttling of miR-17/221 that in turn modulates macrophage beta1 integrin recycling, promoting macrophage recruitment and ultimately contributing to lung inflammation.
we observed that FRZB (show FRZB Proteins) regulates integrin beta1D expression, its silencing increasing integrin beta1D expression to levels similar to those in controls.
high Bgn (show BGN Proteins) expression levels promote a more dense collagen architecture, leading to increased tissue stiffness. This increased tissue stiffness leads to higher integrin-beta1 expression on melanoma cells, which promotes their invasiveness.
GnT-IVa (show MGAT4A Proteins) may contribute to the malignancy of choriocarcinoma by promoting cell adhesion, migration and invasion through glycosylation of integrin beta1 and LAMP-2 (show LAMP2 Proteins).
High expression of ITGB1 is correlated with metastatic triple negative breast cancer.
miR (show MLXIP Proteins)-183 suppressed cell growth by inhibiting ITGB1 signal pathway and MALAT1 promoted melanoma growth by acting as a ceRNA of miR (show MLXIP Proteins)-183 in melanoma.
Our study suggests that FOXM1 (show FOXM1 Proteins) transcription factor regulates Integrin b1 gene expression and that FOXM1 (show FOXM1 Proteins)/ Integrin-b1/FAK (show PTK2 Proteins) axis may play an important role in the progression of Triple-negative breast cancer
SDF-1 (show CXCL12 Proteins) upregulates the number of adherent tumor cells by responding to matrix stiffness via promoting the expression of integrin beta1, which is abolished by blocking of integrin beta1. These results may provide a novel point of view for the mechanism of "organ specificity" phenomenon in tumor metastasis, which in turn contribute to a rational development of new drugs for cancer
We demonstrate that ANGPT2 (show ANGPT2 Proteins) signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (show TEK Proteins) receptor and partly directly via tumor cell surface integrin &1.
Our data suggest a previously unanticipated link between CAS (show CSE1L Proteins) and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype.
Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK (show PTK2 Proteins) to supports stem cell self-renewal.
beta1-integrin antigen-antibody interactions and the distribution of beta1-integrin protein on spermatogonial stem cell membrane were demonstrated using atomic force microscopy
The overall findings suggest that the secreted galectin-3 (show LGALS3 Proteins) stimulated by PGF (show PGF Proteins) plays a role in structural luteolysis by binding to beta 1 integrin.
Putative function of fibronectin (show FN1 Proteins) and its receptor (integrin alpha(5 (show ITGA5 Proteins))beta(1)) in male and female gametes during bovine fertilization in vitro.
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myosin light chain diphosphorylation.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
both the gpIb-VWF (show VWF Proteins) interaction and the integrin alpha(2 (show ITGA2 Proteins))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (show VWF Proteins) is bound
TRPV4 (show TRPV4 Proteins) channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
integrin beta 1
, integrin beta-1*
, integrin beta-1-B
, VLA-4 subunit beta
, fibronectin receptor subunit beta
, integrin beta-1
, beta OL
, beta oligodendroglia
, integrin VLA-4 subunit beta
, integrin beta 1 (fibronectin receptor beta)
, glycoprotein IIa
, integrin VLA-4 beta subunit
, very late activation protein, beta polypeptide
, integrin beta-1 subunit
, CSAT antigen
, JG22 antigen
, Fibronectin receptor subunit beta
, Integrin VLA-4 subunit beta
, Integrin subunit beta-1