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Human Occludin Protein expressed in Wheat germ - ABIN1313322
Grozdanovic, Čavić, Nešić, Andjelković, Akbari, Smit, Gavrović-Jankulović: Kiwifruit cysteine protease actinidin compromises the intestinal barrier by disrupting tight junctions. in Biochimica et biophysica acta 2016
The C-terminal DSP domain induced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576). Coexpression of DSP, occludin and FAK was detected in dental mesenchymal cells during tooth development. Occludin physically interacts with FAK, and occludin and FAK phosphorylation can be blocked by DSP and occludin antibodies.
Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1 (show TJP1 Proteins).
The zinc sensing receptor, ZnR/GPR39 (show GPR39 Proteins), triggers intracellular Ca(2 (show CA2 Proteins)+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 (show GPR39 Proteins) is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS (show PMP22 Proteins)) ulcerative colitis model.
Occludin expression by epidermal gammadelta T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells.
Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin proteolysis and claudin-3 (show CLDN3 Proteins) transcription.
miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in diabetes mellitus mice.
STAT3 (show STAT3 Proteins) activation downregulates the ZO-1 (show TJP1 Proteins) and occludin levels and increases the endothelial permeability through the induction of VEGF (show VEGFA Proteins) production in retinal endothelial cells.
Tricellulin (show MARVELD2 Proteins) is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro.
These findings provide evidence for occludin playing a role in the invasion of Toxoplasma gondii in small intestinal epithelial cells.
occludin deficiency increases susceptibility to ethanol-induced colonic mucosal barrier dysfunction and liver damage in mice.
ZO-1 (show TJP1 Proteins) and occludin are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin at the blastocyst stage.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (show ROS1 Proteins) generation, cell permeability, levels of ICAM-1 (show ICAM1 Proteins), and the tight-junction protein occludin
the presence of occludin at the membrane is dependent in part on calcium-sensitive signaling cascades
cyclic strain modulates both the expression and phosphorylation state of occludin and ZO-1 (show TJP1 Proteins) in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
These data demonstrate a novel mechanism of VEGF (show VEGFA Proteins)-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability.
our findings for the first time identify the role of occludin as a tumor promoter and a prometastatic factor in lung cancer, demonstrating that occludin is a potential prognostic biomarker and therapeutic target in lung cancer
Occludin protein may contribute to the development of cervical cancer. However, it was not correlated with the clinical features.
Low occludin expression is associated with Renal cell carcinoma (show MOK Proteins).
decreased interaction between ZO-1 (show TJP1 Proteins) and occludin might contribute to the epiphora occurred in the transplanted submandibular glands
integration of claudin-2 (show CLDN2 Proteins), occludin and ZO-1 (show TJP1 Proteins) is necessary for maintaining the function of the proximal tubular epithelium.
Molecular studies of the OCLN gene (NM_001205254) identified six distinct candidate mutations in polymicrogyria.
Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome. In contrast, occludin expression was not significantly modified by glutamine.
Viral infectivity was significantly reduced by miR (show MLXIP Proteins)-200c but enhanced by miR (show MLXIP Proteins)-122.
The mechanism of transition from nondifferentiated to differentiated states in HepaRG cells was studed by proteomics. Two key factors (MMP-14 (show MMP14 Proteins) and OCLN) were validated by qRT-PCR and Western blot.
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
, tight-junction protein
, thiopurine methyltransferase
, tight junction protein occludin